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Anna Barnard on Muck Rack

Anna Barnard

As seen in: Nature, Wiley Online Library, MDPI, Imperial College (London), BioRxiv, BiggerPockets, Chemistry World, RealClear Defense, The Boar, Owatonna People's Press and
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Articles

Optimized Sample Handling Minimizes Peptide Adsorption to Plastics to Enable High Sensitivity Evosep Based Chemical Proteomics

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By Anne Schuhmacher, Edward Tate, Anna Barnard
| Wiley Online Library Verified
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New publication in Nature Communications

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By Anna Barnard
| Imperial College (London)
Our latest work using peptide tools to understand DNA replication is out in Nature Communications This project was the work of former PhD student in the group, Joshua Tomkins, working in collaboration with Christian Speck and Alexis Barr at the Laboratory of Medical Sciences (LMS). We used peptides mimicking sections of the protein geminin to understand how it regulates DNA replication - an important cancer target.
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Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions - Nature Communications

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By Matthew Peach Verified, Anna Schmidt, Nicholas Sim, J. Julian Blow, Alexis Barr, Anna Barnard, Joshua Tomkins
| Nature Verified
Abstract DNA replication is tightly regulated to occur once per cell cycle, with the MCM2-7 helicase loaded onto replication origins only during G1-phase. In higher eukaryotes, geminin negatively regulates this process during S-, G2- and M-phases by binding the essential licensing factor CDT1. Although geminin’s function is crucial for genomic stability, its inhibitory mechanism remains elusive. Here, we utilise a fully reconstituted human DNA replication licensing assay to dissect geminin’s role.
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