Anna Bartlett
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News Editor @bbcnorthampton, journalist, reporter, newsreader; busy working mum of boys (views expressed are mine etc)
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Articles by Anna Bartlett
Human body single-cell atlas of three-dimensional genome organization and DNA methylation
Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Structured Abstract INTRODUCTION Each cell type in the human body maintains a distinct identity through a specific program of gene expression.
Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain
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Results We refined and employed snmC-seq3,35,36 an advanced single-nucleus methylome sequencing technique, to achieve base-resolution profiling of genome-wide 5-methylcytosine (5mC) across eight brain regions in C57BL/6 male mice (Figure 1A).
By Qiurui Zeng, Wenliang Wang, Wei Tian, Amit Klein, Anna Bartlett Verified, Hanqing Liu, Joseph R. Nery, Rosa Castanon, Julia Osteen, Nicholas Johnson, Wubin Ding, Huaming Chen, Jordan Altshul, Mia Kenworthy, Cynthia Valadon, William Owens, Zhanghao Wu, Maria Amaral, Nathan R. Zemke, Yuru Song, Silvia Cho, Jonathan A. Rink, Jasper Lee, Nora E. Emerson, Yuancheng Lu, Bing Ren, M. Margarita Behrens, Joseph R. Ecker, Cindy Tatiana Báez-Becerra, Chumo Chen, Jackson Willier, Stella Cao, Ariana Barcoma, Jessica Arzavala
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Cell Press
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Genetics and environment distinctively shape the human immune cell epigenome - Nature Genetics
Abstract The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-accessible chromatin using sequencing (ATAC–seq) to systematically explore how pathogen and chemical exposures, along with genetic variation, are associated with changes in the immune cell epigenome.
"Single-Cell Dna Methylome and 3D Multi-Omic Atlas of the Adult Mouse B" by Hanqing Liu, Qiurui Zeng et al.
Cytosine DNA methylation is essential in brain development and is implicated in various neurological disorders. Understanding DNA methylation diversity across the entire brain in a spatial context is fundamental for a complete molecular atlas of brain cell types and their gene regulatory landscapes.
Retraction Notice to: Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers
Main text (Cell 179, 373–391.e1–e27; October 3, 2019) This article has been retracted at the request of the authors. In this publication, we, the authors, described two induction mechanisms that lead to the expression of NPAS4 and the formation of stimulus-specific heterodimers. After unsuccessful efforts within the Bloodgood lab to recapitulate the core results, we reexamined the original image files and uncovered irregularities associated with data collected and analyzed by the first author, G.
90 Seconds to Midnight: The Inconsistencies of Time in International Relations
In her inaugural address as the Montague Burton Chair in International Relations, Neta Crawford brought into focus the discrepancies inherent in conceptions of time and their consequences for the realm of politics. The prevailing ecological and political crises witnessed in contemporary society are, in part, a product of these discordant temporal perceptions.
Author Correction: Conserved and divergent gene regulatory programs of the mammalian neocortex - Nature
Correction to: Nature https://doi.org/10.1038/s41586-023-06819-6 Published online 13 December 2023 In the version of the article initially published, in Figs. 2c and d and 5e, numbers in labels had been rounded. These have been corrected to exact numbers. In Fig. 2c and d, the labels now read “Mammal level 3 (16,068)”, “Human biased ↑ (10,743)” and “Human biased ↓ (1,105)”. Labels in Fig.
Conserved and divergent gene regulatory programs of the mammalian neocortex - Nature
Abstract Divergence of cis-regulatory elements drives species-specific traits1, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains unclear. Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse using single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal conformation profiles from a total of over 200,000 cells.
Human Immune Cell Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures
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Single-cell DNA Methylome and 3D Multi-omic Atlas of the Adult Mouse Brain
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The World Beyond OX1 - Week 8
Australia and India agree to greater economic and security cooperation On a trip to New Delhi, Australian Prime Minister Anthony Albanese announced an agreement with his Indian counterpart Narendra Modi to strengthen economic and security cooperation between their two nations. The economic side of the agreement promised to finalise a long-stuck bilateral free trade agreement that could potentially double trade between the nations.
The World Beyond OX1 - Week 7
EU and UK finally reach breakthrough deal on Northern Ireland After years of limbo, the EU and UK have finally reached an agreement to settle the issues plaguing a post-Brexit Northern Ireland.
The World Beyond OX1 - Week 6
The EU plans to collectively purchase armaments for the first time European officials have backed growing calls for the EU to start a joint procurement programme for military aid to Ukraine. Defence spending is a national, rather than EU, competency, and under the current arrangement military donors have sent materiel aid to Ukraine individually.
The World Beyond OX1 - Week 5
Germany’s intake of Ukrainian refugees surpasses Syria, Afghanistan, and Iraq migrant crisis Over one million Ukrainians entered Germany in 2022, surpassing in one year the total number of refugees taken in from Syria, Afghanistan, and Iraq during the 2014-2016 refugee crisis. Concerns have grown over the government’s ability to handle such a large and sudden influx of refugees, with local governments demanding more funds to help accommodate them.
The World Beyond OX1 - Week 4
Western states launch more sanctions on Russian oil The G7, EU and Australia have agreed to impose another set of sanctions on Russian oil, in the form of a price cap on remaining Russian oil exports. The upper limits of $100 per barrel for diesel, and $45 per barrel on oil products selling for less than crude oil are aimed at reducing the Kremlin’s revenues from energy exports, and their ability to fund their invasion of Ukraine.
The World Beyond OX1 - Week 3
The EU launches plan to catch up to US green spending The EU has begun plans to loosen rules on government subsidies for industry to counter the economic impact of President Biden’s huge $369bn green spending package in the US.
The World Beyond OX1 - Week 2
Breakthrough as Germany and US to Send Tanks to Ukraine After months of dithering, Germany has finally agreed to send main battle tanks to Ukraine, in tandem with the US. The breakthrough came as German Chancellor Olaf Scholz attracted criticism from Kyiv and Western allies for refusing to send tanks without the US doing so first, and his new defence minister disappointed allies when tanks were again refused at a meeting of Ukraine military backers last week.
Climate anxiety: a narrative in need of change
In contrast to the stereotype of the spirited young student, brandishing placards on the streets of university towns, British students today appear to be politically disengaged. As Brazilian students took to the streets over Bolsenaro’s sweeping education cuts, British students seem to accept their fate entering a post-pandemic economy with a distinct lack of adequate skilled work, and a dismembered housing market in a kind of apathetic stupor.
The World Beyond OX1 - Week 1
Mass strikes in France against Macron’s Retirement Reform Strikes and protests numbering over one million participants erupted across France on Thursday, in opposition to President Emmanuel Macron’s proposed retirement reforms. The strike encompassed workers from a variety of sectors, including transport, education, shipping, and media. In Paris alone 80,000 protesters took to the streets, where police deployed tear gas and made over 20 arrests.
The World Beyond OX1: Vacation Roundup
Inflation slows across the West High levels of inflation that have plagued Western nations throughout 2022 showed positive signs towards the end of the year, with the US and EU recording lower-than-expected inflation levels in December.
Ecology & Society
Synthesis ABSTRACT Traditional flood risk paradigms and associated strategies are no longer sufficient to address global flood adaptation challenges due to climate change and continued development in floodplains. The current flood adaptation approach is failing to take advantage of the benefits provided by intact ecosystems and perpetuates social and economic inequities, leaving those who are most vulnerable at highest risk.
"Leaf Fiber Strength and Fruit Nutrient Content of Yucca Species Native" by Anna Therese Bartlett
Abstract The strength of leaf fibers and the nutritional value of the edible fruit of several yucca species native to the U.S. southwest were studied to aid in the determination of species best suited for commercial cultivation by the Navajo Nation. The leaves were softened in an autoclave to facilitate the removal of the leaf matrix, conditioned in environmentally controlled chambers, and the fibers were broken using a texture analyzer.
Mapping genome-wide transcription-factor binding sites using DAP-seq
The binding of TFs to specific locations in a genome results in dynamic transcriptional changes that drive a vast array of cellular processes, including development and environmental response. Disruption of TFBSs has been associated with phenotypic diversity, including agriculturally important adaptive traits1 and various disease states such as cancer2. Characterization of the genome-wide binding profiles of individual TFs is essential for identifying the mechanisms underlying these changes.
Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page. ResourceCistrome and Epicistrome Features Shape the Regulatory DNA Landscape Ronan C. O’MalleyxRonan C. O’MalleySearch for articles by this authorAffiliationsGenomic Analysis Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USAPlant Biology Laboratory, The Salk Institute for Biological Studies, 10010 N.
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