Anna Bartlett
Verified
News Editor @bbcnorthampton, journalist, reporter, newsreader; busy working mum of boys (views expressed are mine etc)
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Human body single-cell atlas of three-dimensional genome organization and DNA methylation
Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Structured Abstract INTRODUCTION Each cell type in the human body maintains a distinct identity through a specific program of gene expression.
Cell-type-specific transposon demethylation and TAD remodeling in aging mouse brain
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Results We refined and employed snmC-seq3,35,36 an advanced single-nucleus methylome sequencing technique, to achieve base-resolution profiling of genome-wide 5-methylcytosine (5mC) across eight brain regions in C57BL/6 male mice (Figure 1A).
By Qiurui Zeng, Wenliang Wang, Wei Tian, Amit Klein, Anna Bartlett Verified, Hanqing Liu, Joseph R. Nery, Rosa Castanon, Julia Osteen, Nicholas Johnson, Wubin Ding, Huaming Chen, Jordan Altshul, Mia Kenworthy, Cynthia Valadon, William Owens, Zhanghao Wu, Maria Amaral, Nathan R. Zemke, Yuru Song, Silvia Cho, Jonathan A. Rink, Jasper Lee, Nora E. Emerson, Yuancheng Lu, Bing Ren, M. Margarita Behrens, Joseph R. Ecker, Cindy Tatiana Báez-Becerra, Chumo Chen, Jackson Willier, Stella Cao, Ariana Barcoma, Jessica Arzavala
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Cell Press
Verified
Genetics and environment distinctively shape the human immune cell epigenome - Nature Genetics
Abstract The epigenome of human immune cells is shaped by both genetics and environmental factors, yet the relative contributions of these influences remain incompletely characterized. Here we use single-nucleus methylation sequencing and assay for transposase-accessible chromatin using sequencing (ATAC–seq) to systematically explore how pathogen and chemical exposures, along with genetic variation, are associated with changes in the immune cell epigenome.
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