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Introduction Understanding the function and dynamics of nerve fibres is fundamental to advancing our knowledge of the nervous system and developing treatments for neurological conditions. Unmyelinated axons play a crucial role in transmitting sensory signals, particularly in nociception and pain signalling (Dubin & Patapoutian, 2010). They are also abundantly present in the central nervous system (Soleng et al., 2003; Westenbroek et al., 1989).
ResourceOnline nowOpen access 1Institute of Neurophysiology, Uniklinik RWTH Aachen University, Aachen, Germany 2Department of Anesthesiology, Uniklinik RWTH Aachen University, Aachen, Germany 3Department of Intensive and Intermediate Care, Uniklinik RWTH Aachen University, Aachen, Germany 4Scientific Center for Neuropathic pain Aachen SCN-AACHEN, Uniklinik RWTH Aachen University, Aachen, Germany 5Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada...
Abstract Voltage-gated sodium channels (VGSC) are responsible for the fast upstroke of an action potential (AP). In the peripheral nervous system, e.g., in sensory neurons responsible for detection of potentially painful stimuli, subthreshold depolarizations support the initiation of an AP. Nav1.7 was suggested to be a subthreshold channel, and recent studies from human cells assign it a role as threshold channel.
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