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Ariana L. Tucker

As seen in: Nature
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Articles

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration

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By Desiree Ramirez, Sarah L. Parylak, Leslie Wallace, James Tucker, Joel Erberich, Iryna Gallina, Jillybeth Burgado, Baptiste N. Jaeger, Jerika J. Barron, Joshua Pratt, Monique Peña, Christina Lim, Sarah Fernandes, Simone Kastropil Benassi, Lynne Randolph-Moore, Krishna C. Vadodaria, Maria C. Marchetto, Nicola J. Allen, Fred Gage, Ioana I. N. Da Silva, Rutvi Katariya, Aidan H. McDonald, Ariana L. Tucker, Vipula Racha
| Nature Verified
Abstract Neuroinflammation plays a key role in Alzheimer’s disease (AD) and many other neurodegenerative disorders. Chronic activation of astrocytes and microglia fuels neuronal damage via cytokine secretion, oxidative stress, and proteolysis, yet glial inflammatory regulation remains poorly understood. Using chemoproteomics, we identified CK2, particularly the brain-enriched catalytic subunit CK2α2, as a key driver of astrocytic inflammation.
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