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Fred Gage

As seen in: Nature, Wiley Online Library, Frontiers, Scientific American, EurekAlert!, Genome Medicine, Science Magazine, BioRxiv, Cell Metabolism, Cell Press and
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Articles

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration

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By Desiree Ramirez, Sarah L. Parylak, Leslie Wallace, James Tucker, Joel Erberich, Iryna Gallina, Jillybeth Burgado, Baptiste N. Jaeger, Jerika J. Barron, Joshua Pratt, Monique Peña, Christina Lim, Sarah Fernandes, Simone Kastropil Benassi, Lynne Randolph-Moore, Krishna C. Vadodaria, Maria C. Marchetto, Nicola J. Allen, Fred Gage, Ioana I. N. Da Silva, Rutvi Katariya, Aidan H. McDonald, Ariana L. Tucker, Vipula Racha
| Nature Verified
Abstract Neuroinflammation plays a key role in Alzheimer’s disease (AD) and many other neurodegenerative disorders. Chronic activation of astrocytes and microglia fuels neuronal damage via cytokine secretion, oxidative stress, and proteolysis, yet glial inflammatory regulation remains poorly understood. Using chemoproteomics, we identified CK2, particularly the brain-enriched catalytic subunit CK2α2, as a key driver of astrocytic inflammation.
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Adult neurogenesis: New neurons, new opportunities

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By Birte Doludda, Warsha Barde, Francesco D’Egidio, Carlos P Fitzsimons, Jonas Frisén, Fred Gage, Sebastian Jessberger, Orly Lazarov, Paul J. Lucassen, Chiara de Lucia, Evgenia Salta, Hongjun Song, Juan Song, Sandrine Thuret, Tomohisa Toda, Gerd Kempermann, D. Chichung Lie
| Cell Stem Cell Verified
Keywords hippocampus plasticity learning stem cells neural networks Introduction Adult neurogenesis has always been good for discussions. After its original description by Joseph Altman and Gopal Das in 1965,1 it remained an intriguing curiosity for decades that inspired speculation but never entered mainstream neurobiological concepts.
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Differential effects of lithium on metabolic dysfunctions in astrocytes derived from bipolar disorder patients - Molecular Psychiatry

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By Dayeon Kim, Geurim Son, Hyunsu Do, Gyu-Bum Yeon, Ji-Hoon Son, Mingyu Ju, InSook Ahn, Haeun Lee, Sungwoo Choi, Jae Myoung Suh, Jinsoo Seo, Fred Gage, Dae-Sung Kim
| Nature Verified
Abstract Metabolic alterations have been observed in the brains of patients with bipolar disorder (BD), a neuropsychiatric disorder characterized by alternating episodes of mania and depression. However, the specific contributions of glial cells to these metabolic changes remain largely unknown. Here, we investigate the metabolic characteristics of induced astrocytes (iAstrocytes) derived from induced pluripotent stem cells of BD patients—classified by lithium responsiveness—and healthy controls.
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