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Jillybeth Burgado

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Articles

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration

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By Desiree Ramirez, Sarah L. Parylak, Leslie Wallace, James Tucker, Joel Erberich, Iryna Gallina, Jillybeth Burgado, Baptiste N. Jaeger, Jerika J. Barron, Joshua Pratt, Monique Peña, Christina Lim, Sarah Fernandes, Simone Kastropil Benassi, Lynne Randolph-Moore, Krishna C. Vadodaria, Maria C. Marchetto, Nicola J. Allen, Fred Gage, Ioana I. N. Da Silva, Rutvi Katariya, Aidan H. McDonald, Ariana L. Tucker, Vipula Racha
| Nature Verified
Abstract Neuroinflammation plays a key role in Alzheimer’s disease (AD) and many other neurodegenerative disorders. Chronic activation of astrocytes and microglia fuels neuronal damage via cytokine secretion, oxidative stress, and proteolysis, yet glial inflammatory regulation remains poorly understood. Using chemoproteomics, we identified CK2, particularly the brain-enriched catalytic subunit CK2α2, as a key driver of astrocytic inflammation.
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A remote lecture series roadmap to equity, diversity, and inclusion in STEM

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By Evan Boyle, Gabriela Goldberg, Jonathan C. Schmok, Jillybeth Burgado
| biorxiv.org
New Results View ORCID ProfileEvan A. Boyle, View ORCID ProfileGabriela Goldberg, Jonathan C. Schmok, Jillybeth Burgado, Fabiana Izidro Layng, View ORCID ProfileHannah A. Grunwald, View ORCID ProfileKylie M. Balotin, View ORCID ProfileMichael S. Cuoco, View ORCID ProfileKeng-Chi Chang, View ORCID ProfileGertrude Ecklu-Mensah, View ORCID ProfileAleena K. S.
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