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Keywords CAR T cell therapy glioblastoma longitudinal dynamics tumor microenvironment immunotherapy biomarkers immunology single-cell transcriptomics NK cells regulatory T cells myeloid immunosuppression Introduction Although chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies,1,2 translating this success to solid tumors has proven challenging.3,4 Key barriers include antigen paucity, inefficient T cell trafficking, tumor heterogeneity,...
Keywords CAR T cell therapy glioblastoma longitudinal dynamics tumor microenvironment immunotherapy biomarkers immunology single-cell transcriptomics NK cells regulatory T cells myeloid immunosuppression Introduction Although chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies,1,2 translating this success to solid tumors has proven challenging.3,4 Key barriers include antigen paucity, inefficient T cell trafficking, tumor heterogeneity,...
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.