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Shridhar Parthasarathy on Muck Rack

Shridhar Parthasarathy

As seen in: Wiley Online Library, MDPI, BioRxiv, Cell Press, The American Journal of Human Genetics, medRxiv
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Articles

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM

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By Nelson F. Freeburg, Daniel Chafamo, Gayathri Konanur Gopikrishna, Regan Murphy, Jacqueline Peng, Shridhar Parthasarathy, Sydney Dumont, Edward G Estrada, Meghan T. Logun, Yusha Sun, Xin Wang, Payal Grover, Jesse Rodriguez, Daniel Zhang, Kristen Park, Yao Fu, Nadine Ben Hamouda, Isaias Hernandez-Verdin, Lamia Lamrani, Kelly Hicks, Natalie Cooper, Christina Ekwegbara, Emma Bawden, Joshua J. Waterfall, Jaime Fuentealba, Marion Alcantara, John T Seykora, Stephen Prouty, David Barrett, esha banerjee, Arin Cox, Charles-Antoine Assenmacher, Camilla Macia, Melinda Yin, Erica Carpenter, Guo-li Ming, Catherine Sautès-Fridman, Wolf H. Fridman, Eric Tartour, E. John Wherry, Sebastian Amigorena, Joseph A Fraietta, MacLean P. Nasrallah, Hongjun Song, Tyler Miller, Stephen J. Bagley, Donald M. O’Rourke, Zev A. Binder, Cécile Alanio, Dana Silverbush
| Cell Press Verified
Keywords CAR T cell therapy glioblastoma longitudinal dynamics tumor microenvironment immunotherapy biomarkers immunology single-cell transcriptomics NK cells regulatory T cells myeloid immunosuppression Introduction Although chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies,1,2 translating this success to solid tumors has proven challenging.3,4 Key barriers include antigen paucity, inefficient T cell trafficking, tumor heterogeneity,...
Open in Who Shared Issue with article?

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM

|
By Nelson F. Freeburg, Daniel Chafamo, Gayathri Konanur Gopikrishna, Regan Murphy, Jacqueline Peng, Shridhar Parthasarathy, Sydney Dumont, Edward G Estrada, Meghan T. Logun, Yusha Sun, Xin Wang, Payal Grover, Jesse Rodriguez, Daniel Zhang, Kristen Park, Yao Fu, Isaias Hernandez-Verdin, Kelly Hicks, Natalie Cooper, Emma Bawden, Joshua J. Waterfall, Jaime Fuentealba, Marion Alcantara, John T Seykora, Stephen Prouty, David Barrett, esha banerjee, Charles-Antoine Assenmacher, Erica Carpenter, Guo-li Ming, Catherine Sautès-Fridman, Wolf H. Fridman, Eric Tartour, E. John Wherry, Sebastian Amigorena, Joseph A Fraietta, MacLean P. Nasrallah, Hongjun Song, Tyler Miller, Stephen J. Bagley, Donald M. O’Rourke, Zev A. Binder, Cécile Alanio, Dana Silverbush, Nadine Ben Hamouda, Lamia Lamrani, Christina Ekwegbara, Arin Cox, Camilla Macia, Melinda Yin
| Cell Press Verified
Keywords CAR T cell therapy glioblastoma longitudinal dynamics tumor microenvironment immunotherapy biomarkers immunology single-cell transcriptomics NK cells regulatory T cells myeloid immunosuppression Introduction Although chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies,1,2 translating this success to solid tumors has proven challenging.3,4 Key barriers include antigen paucity, inefficient T cell trafficking, tumor heterogeneity,...
Open in Who Shared Issue with article?

Phenotypic analysis of 11,125 trio exomes in neurodevelopmental disorders

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By Shiva Ganesan, Sarah M Ruggiero, Shridhar Parthasarathy, Peter D. Galer
| BioRxiv
Abstract Genomic sequencing is widely used to identify causative genetic changes in neurodevelopmental disorders, such as autism, intellectual disability, and epilepsy. Most neurodevelopmental disorders also present with diverse clinical features, and delineating the interaction between causative genetic changes and phenotypic features is a key prerequisite for developing personalized therapies. However, assessing clinical features at a scale that parallels genomic sequencing remains challenging.
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