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Articles

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM

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By Nelson F. Freeburg, Daniel Chafamo, Gayathri Konanur Gopikrishna, Regan Murphy, Jacqueline Peng, Shridhar Parthasarathy, Sydney Dumont, Edward G Estrada, Meghan T. Logun, Yusha Sun, Xin Wang, Payal Grover, Jesse Rodriguez, Daniel Zhang, Kristen Park, Yao Fu, Nadine Ben Hamouda, Isaias Hernandez-Verdin, Lamia Lamrani, Kelly Hicks, Natalie Cooper, Christina Ekwegbara, Emma Bawden, Joshua J. Waterfall, Jaime Fuentealba, Marion Alcantara, John T Seykora, Stephen Prouty, David Barrett, esha banerjee, Arin Cox, Charles-Antoine Assenmacher, Camilla Macia, Melinda Yin, Erica Carpenter, Guo-li Ming, Catherine Sautès-Fridman, Wolf H. Fridman, Eric Tartour, E. John Wherry, Sebastian Amigorena, Joseph A Fraietta, MacLean P. Nasrallah, Hongjun Song, Tyler Miller, Stephen J. Bagley, Donald M. O’Rourke, Zev A. Binder, Cécile Alanio, Dana Silverbush
| Cell Press Verified
Keywords CAR T cell therapy glioblastoma longitudinal dynamics tumor microenvironment immunotherapy biomarkers immunology single-cell transcriptomics NK cells regulatory T cells myeloid immunosuppression Introduction Although chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies,1,2 translating this success to solid tumors has proven challenging.3,4 Key barriers include antigen paucity, inefficient T cell trafficking, tumor heterogeneity,...
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The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM

|
By Nelson F. Freeburg, Daniel Chafamo, Gayathri Konanur Gopikrishna, Regan Murphy, Jacqueline Peng, Shridhar Parthasarathy, Sydney Dumont, Edward G Estrada, Meghan T. Logun, Yusha Sun, Xin Wang, Payal Grover, Jesse Rodriguez, Daniel Zhang, Kristen Park, Yao Fu, Isaias Hernandez-Verdin, Kelly Hicks, Natalie Cooper, Emma Bawden, Joshua J. Waterfall, Jaime Fuentealba, Marion Alcantara, John T Seykora, Stephen Prouty, David Barrett, esha banerjee, Charles-Antoine Assenmacher, Erica Carpenter, Guo-li Ming, Catherine Sautès-Fridman, Wolf H. Fridman, Eric Tartour, E. John Wherry, Sebastian Amigorena, Joseph A Fraietta, MacLean P. Nasrallah, Hongjun Song, Tyler Miller, Stephen J. Bagley, Donald M. O’Rourke, Zev A. Binder, Cécile Alanio, Dana Silverbush, Nadine Ben Hamouda, Lamia Lamrani, Christina Ekwegbara, Arin Cox, Camilla Macia, Melinda Yin
| Cell Press Verified
Keywords CAR T cell therapy glioblastoma longitudinal dynamics tumor microenvironment immunotherapy biomarkers immunology single-cell transcriptomics NK cells regulatory T cells myeloid immunosuppression Introduction Although chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies,1,2 translating this success to solid tumors has proven challenging.3,4 Key barriers include antigen paucity, inefficient T cell trafficking, tumor heterogeneity,...
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Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in the PARL deficient mouse model of Leigh Syndrome

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By Enrico Radaelli, Charles-Antoine Assenmacher, esha banerjee, Jillian Verrelle
| eLife
Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript published July 28, 2023 (This version) Accepted July 23, 2023 Received November 5, 2022 Share this article Cite this article Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in the PARL deficient mouse model of Leigh Syndrome eLife 12:e84710.
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