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Arnita Barnes on Muck Rack

Arnita Barnes

As seen in: The Journal of Biological Chemistry
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Articles

Crystal structure of the human 4-1BB/4-1BBL complex

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By Vaheh Oganesyan, Hamza Amdouni, Shabazz Novarra, Arnita Barnes
| The Journal of Biological Chemistry Verified
4-1BBL is a member of the tumor necrosis factor (TNF) superfamily and is the ligand for the TNFR superfamily receptor, 4-1BB. 4-1BB plays an immunomodulatory role in T cells and NK cells, and agonists of this receptor have garnered strong attention as potential immunotherapy agents. Broadly speaking, the structural features of TNF superfamily members, their receptors, and ligand-receptor complexes are similar.
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