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Dynamics of genetic and somatic trade-offs in ageing and mortality

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By Danny Arends, David G. Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur Centeno, Kurt Lamour, Pjotr Prins, Karl Broman, Saunak Sen, Sarah Mitchell, Michael R. MacArthur, Ozlem Akin, Xiaoxu Li, Amandeep Bajwa, Vivian Diaz, David Harrison, Randy Strong, James Nelson, Khyobeni Mozhui, Johan Auwerx, Evan Williams, Richard Miller, Robert Williams, João Pedro de Magalhães
| Nature Verified
Abstract DNA variants modulate mortality risks across an entire lifespan but their dynamic age-dependent effects have not been resolved in any species for either sex. Here we mapped variants that shape mortality using an actuarial approach, starting with a base population of 6,438 pubescent mice and ending with 559 survivors that lived beyond 1,100 days of age. Twenty-nine Vita loci influence lifespan with strong age- and sex-specific effects.
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