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Robert Williams on Muck Rack

Robert Williams

Memphis
As seen in: AWWA Opflow, Nature, Wiley Online Library, Memory Studies, MDPI, ACS Publications, Social Media Today, MediaPost, ASM Journals, Paulick Report and
Genetics•vision•aging•addiction•FOSS•FAIR data•neural networks•AI•time•consciousness UTHSC UT-ORNL Governor’s Chair Computational Genomics—labwilliams@gmail.com
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Articles

Dynamics of genetic and somatic trade-offs in ageing and mortality

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By Danny Arends, David G. Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur Centeno, Kurt Lamour, Pjotr Prins, Karl Broman, Saunak Sen, Sarah Mitchell, Michael R. MacArthur, Ozlem Akin, Xiaoxu Li, Amandeep Bajwa, Vivian Diaz, David Harrison, Randy Strong, James Nelson, Khyobeni Mozhui, Johan Auwerx, Evan Williams, Richard Miller, Robert Williams, João Pedro de Magalhães
| Nature Verified
Abstract DNA variants modulate mortality risks across an entire lifespan but their dynamic age-dependent effects have not been resolved in any species for either sex. Here we mapped variants that shape mortality using an actuarial approach, starting with a base population of 6,438 pubescent mice and ending with 559 survivors that lived beyond 1,100 days of age. Twenty-nine Vita loci influence lifespan with strong age- and sex-specific effects.
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Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice - Nature Neuroscience

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By Yuqi Tian, Kathryn J. Hornburg, Wyatt n Austin, James Cook, Yi Qi, Leonard White, Catherine C. Kaczorowski, David G. Ashbrook, G. Allan Johnson, Robert Williams, John T. Killmar
| Nature Verified
Abstract Alzheimer’s disease has widespread effects on brain structure, function and behavior, but we lack a systematic dissection of its impact across hundreds of forebrain and brainstem regions. Here, using diffusion tensor MRI at 25 µm, we mapped the global consequences of mutations in APP and PSEN1 across 231 regions of interest (ROIs) in male and female 5×FAD BXD hybrid mice at 14 months.
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Amyloid-beta induces distinct forms of cell death in different neuronal populations - Cell Death & Differentiation

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By Rosalind Heron, Barbara Monteiro-Black, Robert Williams
| Nature Verified
Abstract Recent FDA approval for treating Alzheimer’s disease (AD) with amyloid-beta (Aβ) immunotherapy is a historic breakthrough, which has rekindled widespread interest in understanding the molecular basis of Aβ toxicity. In this study, we developed a novel Drosophila model to investigate Aβ42-induced pathologies in vivo and in real time.
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