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Richard Miller on Muck Rack

Richard Miller

Indianapolis
As seen in: Nature, Human Reproduction Update, Memory Studies, MDPI, Sydney Morning Herald, Vanity Fair, WSU Insider, BioRxiv, Cell Press, HCP Live and
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Articles

Dynamics of genetic and somatic trade-offs in ageing and mortality

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By Danny Arends, David G. Ashbrook, Suheeta Roy, Lu Lu, Zachary Sloan, Arthur Centeno, Kurt Lamour, Pjotr Prins, Karl Broman, Saunak Sen, Sarah Mitchell, Michael R. MacArthur, Ozlem Akin, Xiaoxu Li, Amandeep Bajwa, Vivian Diaz, David Harrison, Randy Strong, James Nelson, Khyobeni Mozhui, Johan Auwerx, Evan Williams, Richard Miller, Robert Williams, João Pedro de Magalhães
| Nature Verified
Abstract DNA variants modulate mortality risks across an entire lifespan but their dynamic age-dependent effects have not been resolved in any species for either sex. Here we mapped variants that shape mortality using an actuarial approach, starting with a base population of 6,438 pubescent mice and ending with 559 survivors that lived beyond 1,100 days of age. Twenty-nine Vita loci influence lifespan with strong age- and sex-specific effects.
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Evolution of myeloid-mediated immunotherapy resistance in prostate cancer - Nature

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By Aram Lyu, Marcel Arias-Badia, Richard Miller
| Nature Verified
Abstract Patients with advanced metastatic castration-resistant prostate cancer (mCRPC) are refractory to immune checkpoint inhibitors (ICIs)1,2, partly because there are immunosuppressive myeloid cells in tumours3,4. However, the heterogeneity of myeloid cells has made them difficult to target, making blockade of the colony stimulating factor-1 receptor (CSF1R) clinically ineffective.
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Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging

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By Richard Miller
| Nature Verified
Abstract Restricting the intake of protein or the branched-chain amino acid isoleucine promotes healthspan and extends lifespan in young or adult mice. However, their effects when initiated in aged animals are unknown. Here we investigate the consequences of consuming a diet with 67% reduction of all amino acids (low AA) or of isoleucine alone (low Ile), in male and female C57BL/6J.Nia mice starting at 20 months of age.
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