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Asaf Tal

As seen in: BioRxiv, Cell Press
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Articles

CRATER tumor niches facilitate CD8+ T cell engagement and correspond with immunotherapy success

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By Aya Ludin, Georgia L. Stirtz, Asaf Tal, Ajit J Nirmal, Kathleen L. Pfaff, Michael Manos, Naomi R. Besson, Nebiyat Eskndir, Billie JD Porter, Stephanie Jones, Hannah Faulkner, Qiyu Gong, Sophia B. Liu, Irving Barrera, Lijian Wu, Cecilia Pessoa Rodrigues, Cecília Rodrigues, Aditi Sahu, Elizabeth R. Jerison, Joao V Alessi, Biagio Ricciuti, Douglas Richardson, Jodi Weiss, Hadley Moreau, Alexander B. Afeyan, James Sefton, Yi Zhou, Hannah Cole, Miguel Cordova, Liang Deng, Milind Rajadhyaksha, Stephen R. Quake, Mark Awad, fei chen, Kai W. Wucherpfennig, Peter K. Sorger, F. Stephen Hodi, Scott J. Rodig, George Murphy, Leonard I. Zon, Meredith E. Stanhope, Wyatt D. McCall, Emily Formato
| Cell Press Verified
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Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans

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By Aya Ludin, Ajit J Nirmal, Georgia L. Stirtz, Asaf Tal
| BioRxiv
Abstract Immunotherapy leads to cancer eradication despite the tumor's immunosuppressive environment. Here, we used extended long-term in-vivo imaging and high-resolution spatial transcriptomics of endogenous melanoma in zebrafish, and multiplex imaging of human melanoma, to identify domains that facilitate immune response during immunotherapy. We identified crater-shaped pockets at the margins of zebrafish and human melanoma, rich with beta-2 microglobulin (B2M) and antigen recognition molecules.
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