Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Athanasios Ziogas
Reversal of trauma-induced monocyte paralysis by IFN-γ fails to prevent ventilator-associated pneumonia, implicating lymphoid deficits in infection risk
Abstract Ventilator-associated pneumonia (VAP) remains a frequent and severe complication in critically ill patients. Although interferon-gamma (IFN-γ) has been reported to restore trauma-associated immune defects, the PREV-HAP trial (ClinicalTrials.gov NCT04793568) did not show a benefit of IFN-γ on VAP prevention. To investigate the immunological basis of this therapeutic failure, we performed longitudinal high-dimensional immunoprofiling on 104 trial participants.
Interferon-related inflammaging links epigenetic age acceleration to multimorbidity
|
Results Using DNA methylation profiles derived from whole blood, we assessed several epigenetic aging scores in four cohorts of individuals with diverse age and health conditions: BCG-PRIME (n = 384), iMed (n = 165), 300BCG (n = 283), and 500FG (n = 212) cohorts (Figure 1A). The BCG-PRIME and iMed cohorts comprised individuals aged 60 years and above (mean ages: BCG-PRIME, 69 years and iMed, 72 years). 300BCG and 500FG were mainly composed of young, healthy individuals with a mean age of 25 years.
By Zhaoli Liu, Athanasios Ziogas, Yihan Zhang, Manoj Gupta Verified, Konstantin Föhse, Esther J.M. Taks, Elisabeth A. Dulfer, Andrei S. Sarlea, Lorenzo Ventriglia, Büsra Geckin, Mohamad Ballan, Nienke van Unen, Leonie S. Helder, Stephanie Trittel, Peggy Riese, Simone J.C.F.M. Moorlag, Valerie A. C. M. Koeken, Vera P. Mourits, Martin Jaeger, Frank Pessler, Carlos Guzmán Verified, Leo A.B. Joosten, Cheng-Jian Xu, Mihai G. Netea, Charlotte de Bree
|
Cell Press
Verified
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses
Adaptive CD4+ T helper 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) are the main cell types that drive type 2 immune responses to provide protection against helminth infection or promote allergic inflammation.1 Th2 cells, which are primarily activated via engagement of the T cell receptor (TCR), act later during the immune response,2 while ILC2s, which lack TCR, are involved in the initial phase of the immune response.
Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis
Section snippets Macrophage functions beyond host defense Macrophages are dynamic cells of the innate immune system that perform a wide array of functions to protect against pathogens, resolve inflammation, and maintain tissue homeostasis (see Glossary) (Figure 1) [1,2]. Macrophages excel at these heterogeneous functions due to their ability to sense a broad spectrum of environmental cues and communicate these signals to neighboring cells [3].
Alzheimer’s defense: brain CD8+ T cells in action
In a remarkable new study, Su et al. have shown that a specific subpopulation of CD8+ T cells, attracted to brain lesion sites and expanded via microglia-CD8+ T cell CXCL16-CXCR6 intercellular communication, can curb Alzheimer’s disease (AD)-related pathology in mouse models.
DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1
Open Access Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis and Vasileia Ismini Alexaki J Immunol March 1, 2020, 204 (5) 1214-1224; DOI: https://doi.org/10.4049/jimmunol.1900746 Key Points DHEA limits leukocyte recruitment. DHEA restores endothelial DEL-1 expression in inflammation.
DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1
Open Access Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis and Vasileia Ismini Alexaki J Immunol January 24, 2020, ji1900746; DOI: https://doi.org/10.4049/jimmunol.1900746 Key Points DHEA limits leukocyte recruitment. DHEA restores endothelial DEL-1 expression in inflammation.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Athanasios
Contact Athanasios, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack