Yingcheng Wu
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OpenIO: An open framework for AI-native immunotherapy
Get full text access Log in, subscribe or purchase for full access. References 1. Lesterhuis, W.J. ∙ Haanen, J.B.A.G. ∙ Punt, C.J.A. Cancer immunotherapy—revisited Nat. Rev. Drug Discov. 2011; 10:591-600 2. Nguyen, E. ∙ Poli, M. ∙ Durrant, M.G. ... Sequence modeling and design from molecular to genome scale with Evo Science. 2024; 386, eado9336 3. Cui, H. ∙ Wang, C. ∙ Maan, H. ... scGPT: toward building a foundation model for single-cell multi-omics using generative AI Nat. Methods. 2024; 21:1470-1480 4.
Editorial: Cancer metastases: mechanisms of tumor dissemination, formation of metastatic niche and anti-metastatic therapy
Despite decades of progress in treating primary tumors, metastasis remains the final frontier and the central challenge in oncology. At late stages of cancer progression, primary localized tumors may metastasize to distant sites, including bones, lymph nodes, lungs, brain, liver, and other organs. Since current options to treat cancer metastases effectively are highly limited, cancer metastatic disease accounts for approximately 90% of cancer-related deaths.
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses
Adaptive CD4+ T helper 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) are the main cell types that drive type 2 immune responses to provide protection against helminth infection or promote allergic inflammation.1 Th2 cells, which are primarily activated via engagement of the T cell receptor (TCR), act later during the immune response,2 while ILC2s, which lack TCR, are involved in the initial phase of the immune response.
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