Attila Gabor

Abstract Introduction: B-type natriuretic peptide (BNP) is a well-known cardiac hormone and biomarker of heart failure, but emerging evidence suggests that it also possesses immunomodulatory properties, including a role in inflammatory skin conditions like atopic dermatitis (AD). Langerhans cells (LCs), specialized epidermal antigen-presenting cells, orchestrate cutaneous immunity and are targets of neuropeptides.

Abstract Analysing omics data requires computational methods to effectively handle its complexity and to derive meaningful hypotheses about molecular mechanisms. While data-driven statistical and machine learning methods can identify patterns from omics data across multiple samples, they typically require a large number of samples and they often lack interpretability and alignment with existing biological knowledge.

1. Introduction Mast cells (MCs) are multifunctional immune cells that reside in tissues and are involved in various physiological processes such as tissue repair and wound healing, as well as immunity via protection against pathogens or inducing immune tolerance [1].