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Audrey Labarre

As seen in: Nature, BioRxiv
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Articles

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis

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By Romane Manceau, Celena M Cherian, Danie Majeur, Colin Miller, Frederick Boisjoly, Lianna W. Wat, Charlotte F Chao, Audrey Labarre, Sanjana Prakash, Sebastien Audet, Lewis R Depaauw-Holt, Benjamin Rogers, Anthony Bosson, Puja Biswas, Joyce Xi, Niyoosha Yoosefi, Yi Xia, Alisa Hui, Jared Vander Zwaag, Khalil Bouyakdan, Pavel Kotchetkov, Caroline Daneault, Martine Tétreault, Marie-Eve Tremblay, Matthieu Ruiz, Baptiste Lacoste, J. Parker, Ciaran Murphy-Royal, Tao Huan, Stephanie Fulton, Elizabeth Rideout, Thierry Alquier, Jasper D. Fisher, J. Beatrice Liston, Jennifer A. Bako, Serena Hollman, Catrina A. S. Callow, Neele Schikora, Niki Shahraki, Demetra Rodaros, Ghazal Fallahpour
| Nature Verified
Abstract Lipids are essential for neuron development and physiology1,2,3. Yet, the central hubs that coordinate lipid supply and demand in neurons remain unclear4. Here we show the presence and functional significance of neuronal lipid droplets (nLDs) in vivo using invertebrate and vertebrate models. We validate5 the presence of nLDs in vivo and demonstrate that triglyceride metabolism enzymes and LD-associated proteins control nLD formation through both canonical and recently discovered pathways6.
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Mimicking of tau hyperphosphorylation in GABAergic motoneurons of C. elegans induces severe peripheral and neuronal alterations

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By Julie Pilliod, Samuel Boyer, Audrey Labarre, Émilien Schramm
| BioRxiv
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