Ciaran Murphy-Royal

Abstract Lipids are essential for neuron development and physiology1,2,3. Yet, the central hubs that coordinate lipid supply and demand in neurons remain unclear4. Here we show the presence and functional significance of neuronal lipid droplets (nLDs) in vivo using invertebrate and vertebrate models. We validate5 the presence of nLDs in vivo and demonstrate that triglyceride metabolism enzymes and LD-associated proteins control nLD formation through both canonical and recently discovered pathways6.

Keywords astrocytes neuron-glia interactions anxiety encoding basolateral amygdala threat photometry noradrenaline norepinephrine Introduction Anxiety, defined as the anticipation of future threat,1 is an evolutionarily conserved emotional state that promotes survival by enhancing vigilance and avoidance behaviors.

Abstract The participation of astrocytes in brain computation was hypothesized in 1992, coinciding with the discovery that these cells display a form of intracellular Ca2+ signaling sensitive to neuroactive molecules. This finding fostered conceptual leaps crystalized around the idea that astrocytes, once thought to be passive, participate actively in brain signaling and outputs.