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Articles by Aurélien Roux
Complexity of Clathrin Coat Dynamics in Endocytosis
1 Introduction Clathrin-mediated endocytosis is a major pathway eukaryotic cells use for the selective uptake of a wide range of molecules, from hormones and transmembrane proteins to lipids and nutrients. It is a highly conserved internalisation route found across the eukaryotic phylogenetic tree, making it one of the most studied trafficking pathways across model organisms from mammals to plants and fungi, which has provided a good understanding of the inner workings of this complex process.
Chieftain Chatter – News and Notes from Iuka Middle School
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Newspaper – August 2026
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Newspaper – August 2026
Discover more from Tishco News Subscribe now to keep reading and get access to the full archive. Continue reading
Miss. Lawmakers Urge Caution in Implementing New Organ Donation Standards
U.S. Senator Cindy Hyde-Smith, Senator Roger Wicker, and Representative Michael Guest urged the Centers for Medicare and Medicaid Services (CMS) to consider feedback from Mississippi's Organ Recovery Agency regarding changes to organ donation performance metrics. They express concerns that new metrics may jeopardize organ donation efforts in states with high chronic disease rates, like Mississippi. Membership Required You must be a member to access this content. View Membership Levels
NEMCC Campus Police Join Local Agencies for Multi-Day School Safety Training
Over 35 participants from various law enforcement agencies in northeast Mississippi attended a multi-day training at Northeast Mississippi Community College, focusing on school safety and emergency response. The program utilized ALERRT curriculum, combining classroom instruction with scenario-based exercises to prepare officers for real-life incidents involving active threats and coordinated team responses. Membership Required You must be a member to access this content. View Membership Levels
Iuka Board Approves Property Maintenance Code, Utility Rate Changes
During Iuka's monthly meeting, the Mayor and Board addressed utility rate adjustments, adopted a property maintenance code, and advanced infrastructure projects. They discussed storm damage at the library, rezoning requests, and approved several community initiatives. The meeting concluded with plans for the upcoming fiscal year budget. Related
NEMCC Campus Police Promote Digital Safety at Career Development Academy Summer Camp
Northeast Mississippi Community College's Campus Police Department conducted a session on personal and online safety for students at a summer camp. Chief Jason Jackson and Assistant Chief Melissa Pearson discussed digital habits, cyberbullying, and strategies to counter online scams. The session emphasized responsible digital citizenship and maintaining a balance between screen time and life responsibilities. Membership Required You must be a member to access this content. View Membership Levels
TCHS PR Students Bring Campus News to Life Through ‘The Brave Voice,’ ‘TC News Now,’ and Live Sports Coverage
The Tishomingo County High School Public Relations class supports students by producing the student newspaper, "The Brave Voice," and the weekly broadcast "TC News Now." Under Evan Norvell, the program enhances journalism skills while covering campus activities and live-streaming sports events, fostering future communication professionals through hands-on experience. Related
Newspaper – August 2026
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NEMCC Adult Education Offers Free Pathways to Education and Employment
Northeast Mississippi Community College's Adult Education program is starting classes on Aug. 10, aimed at helping local residents earn high school equivalency diplomas, prepare for college, and begin new careers. Various programs are available, including the Gateway Program for young adults, and support for eligible single parents through the MI-BEST Program. Related
Tishomingo County Special Municipal School District Board of Trustees Notice of Candidate Qualifying Period for Districts 1 and 5
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Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes
Abstract In cells, the curved clathrin structures in vesicle budding are well characterized, while the flat ones remain poorly understood. Here, we reconstitute the flat assembly of ESCRT-0 protein HRS and clathrin onto lipid membranes in vitro. HRS forms gel-like protein condensates at micromolar concentrations in solutions. These condensates spread as a two-dimensional layer on negatively charged membranes and, together with clathrin, form multilayered coats.
Quand la physique rencontre la biologie
Accueil Tous les numéros Volume 41 (Octobre 2025) Hors série n° 1 Med Sci (Paris), 41 (2025) 93-96 Full HTML Numéro Med Sci (Paris) Volume 41, Octobre 2025 médecine/sciences Page(s) 93 - 96 Section Biologie cellulaire DOI https://doi.org/10.1051/medsci/2025120 Publié en ligne 10 octobre 2025 Med Sci (Paris) 2025 ; 41 (Hors série n° 1): 93–96 Quand la physique rencontre la biologie 1* et 2** 1 Département biologie cellulaire et cancer, CNRS UMR 144, Institut Curie, Université PSL, Paris,...
Tutorial: fluorescence lifetime microscopy of membrane mechanosensitive Flipper probes - Nature Protocols
Abstract Measuring forces within living cells remains a technical challenge. In this Tutorial, we cover the development of hydrophobic mechanosensing fluorescent probes called Flippers, whose fluorescence lifetime depends on lipid packing. Flipper probes can therefore be used as reporters for membrane tension via the measurement of changes in their fluorescence lifetime.
Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain - Nature
Abstract Biological membranes are partitioned into functional zones termed membrane microdomains, which contain specific lipids and proteins1,2,3. The composition and organization of membrane microdomains remain controversial because few techniques are available that allow the visualization of lipids in situ without disrupting their native behaviour3,4.
Methylation of ESCRT-III components regulates the timing of cytokinetic abscission - Nature Communications
Abstract Abscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB) connecting two daughter cells. Abscission requires tight control of the recruitment and polymerization of the Endosomal Protein Complex Required for Transport-III (ESCRT-III) components. We explore the role of post-translational modifications in regulating ESCRT dynamics.
Flattening out: A new ESCRT structure in cell adhesions
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/ ). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/ ).
Passive transport of Ca2+ ions through lipid bilayers imaged by widefield second harmonic microscopy
Ca2+ translocation We performed SH imaging of a variety of lipid GUV membranes that have the same PC and PA headgroups in a 1:1 mol ratio but different alkyl chains: DOPC:DOPA, DOPC:DOPA:Chol, DPhPC:DPhPA, and SLPC:SLPA. GUVs from these different lipids were imaged repeatedly (period t = 1 min and accumulation time 5 s) after adding 5 mM CaCl2 into the outside solution. Fig.
Integer topological defects organize stresses driving tissue morphogenesis - Nature Materials
Abstract Tissues acquire function and shape via differentiation and morphogenesis. Both processes are driven by coordinating cellular forces and shapes at the tissue scale, but general principles governing this interplay remain to be discovered. Here we report that self-organization of myoblasts around integer topological defects, namely spirals and asters, suffices to establish complex multicellular architectures.
Mechanics of ESCRT-III mediated membrane fission
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Principles of membrane remodeling by dynamic ESCRT-III polymers
Highlights The endosomal protein complex required for transport-III (ESCRT-III) proteins form membrane-remodeling (hetero)polymeric filaments, but how exactly they deform and mediate the fission of lipid membranes is unknown. ESCRT-III subunits adopt different conformations that polymerize into filaments with distinct polymer architectures.
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth
Abstract Lysosomes must maintain the integrity of their limiting membrane to ensure efficient fusion with incoming organelles and degradation of substrates within their lumen. Pancreatic cancer cells upregulate lysosomal biogenesis to enhance nutrient recycling and stress resistance, but it is unknown whether dedicated programmes for maintaining the integrity of the lysosome membrane facilitate pancreatic cancer growth.
An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission
Under a Creative Commons license open access Highlights • ESCRT-III subunits polymerize sequentially at the membrane driven by the ATPase Vps4 • The ESCRT-III polymerization sequence ends by Did2/Ist1 to catalyze membrane fission • Subunit exchange triggers changes in ESCRT-III polymers shape and properties • Tilt introduction in the polymer-membrane interface mediates filament buckling Summary The endosomal sorting complex required for transport-III (ESCRT-III) catalyzes membrane fission...
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation
Abstract The plasma membrane tension strongly affects cell surface processes, such as migration, endocytosis and signalling. However, it is not known whether the membrane tension of organelles regulates their functions, notably intracellular traffic. The endosomal sorting complexes required for transport (ESCRT)-III complex is the major membrane remodelling complex that drives intra-lumenal-vesicle (ILV) formation on endosomal membranes.
Optical control of cytoplasmic flows
Cytoplasmic flows are essential for various cellular processes. However, tools to manipulate these flows within cells are still lacking. Now research shows that an optical tool allows for control of cytoplasmic flows and can be used as a subcellular rheometer.
Mitochondrial Homeostasis: How Do Dimers of Mitofusins Mediate Mitochondrial Fusion?
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