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Buzz Baum on Muck Rack

Buzz Baum

Cambridge
As seen in: Nature, Popular Science, Science Magazine, BioRxiv, Cell Press, eLife, Knowable Magazine, ASCB
all opinions are my own, some aren’t even mine
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Articles

Balancing stability and flexibility when reshaping archaeal membranes

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By Miguel Amaral, Felix Frey, Xiuyun Jiang, Buzz Baum
| eLife
eLife Assessment This fundamental study characterizes the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model. The authors present a robust mesoscale model of bolalipids-containing membranes, systematically evaluating it across diverse membrane configurations.
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Stability vs flexibility: reshaping archaeal membranes in silico

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By Miguel Amaral, Felix Frey, Xiuyun Jiang, Buzz Baum
| BioRxiv
Abstract Across the tree of life, distinct designs of cellular membranes have evolved. In bacteria and eukaryotes single-headed lipids self-assemble into flexible bilayer membranes. By contrast, archaea often possess double-headed, monolayer spanning bolalipids, mixed with bilayer lipids, enabling them to survive in harsh environments. Here, using a minimal computational model for bolalipid membranes, we discover trade-offs when forming membranes.
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Stability vs flexibility: reshaping monolayer and bilayer archaeal membranes in silico

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By Miguel Amaral, Felix Frey, Xiuyun Jiang, Buzz Baum
| BioRxiv
Abstract Across the tree of life, distinct designs of cellular membranes have evolved that are both stable and flexible. In bacteria and eukaryotes this trade-off is accomplished by single-headed lipids that self-assemble into flexible bilayer membranes. By contrast, archaea in many cases possess both bilayer and double-headed, monolayer spanning bolalipids. This composition is believed to enable extremophile archaea to survive harsh environments.
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