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Austin Reilly

As seen in: BioRxiv, Cell Reports, The Journal of Biological Chemistry, The Business Press
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Articles by Austin Reilly

Global impact of aberrant splicing on human gene expression levels

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By Benjamin Fair, Junxing Zhao, Stephanie Lozano, Austin Reilly
| BioRxiv
Abstract Alternative splicing (AS) is pervasive in human genes, yet the specific function of most AS events remains unknown. It is widely assumed that the primary function of AS is to diversify the proteome, however AS can also influence gene expression levels by producing transcripts rapidly degraded by nonsense-mediated decay (NMD).
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Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion

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By Shijun Yan, Metabolic Diseases, Jason Conley, Austin Reilly
| Cell Reports Verified
Highlights • Gpr17 is expressed in GLP-1-producing EECs in human and rodent gut epithelium • Loss of gut Gpr17 increases insulin release and improves glucose tolerance in mice • Gpr17 deficiency increases GLP-1 secretion in mice and intestinal organoids • Gpr17-Gαi/βγ signaling regulates GLP-1 secretion by inhibiting cAMP and VDCCs Summary G protein-coupled receptors (GPCRs) in intestinal enteroendocrine cells (EECs) respond to nutritional, neural, and microbial cues and modulate the release...
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A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues

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By Austin Reilly, Shijun Yan, Metabolic Diseases, Menghao Huang
| The Journal of Biological Chemistry Verified
Abstract Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin receptor knockout (GIRKO) in muscle, adipose, and neuronal subpopulations.
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Westchester Plaza implosion

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By Austin Reilly
| The Business Press Verified
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