Awab Ghulam Rahim on Muck Rack

Awab Ghulam Rahim

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Articles

Microhaplotype deep sequencing assays to capture Plasmodium vivax infection lineages - Nature Communications

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By Edwin Sutanto, Ashley Osborne, Ernest Diez Benavente, Sasha V. Siegel, Richard Pearson, Roberto Amato, Hoang Nguyen Verified, Hoàng Nguyên, Hoàng Nguyễn Verified, Ashenafi Assefa, Awab Ghulam Rahim, Mohammad Shafiul Alam, Diego F. Echeverry, Matthew J Grigg, Nicholas White, Dominic P Kwiatkowski, Aimee Taylor, Daniel E. Neafsey, Ric N. Price, Dagimawie Tadesse Abate
| Nature Verified
Abstract Plasmodium vivax elimination is challenged by dormant liver stages (hypnozoites) that can reactivate months after initial infection resulting in relapses. Relapsing infections confound antimalarial clinical efficacy trials due to the inability to distinguish between recurrences arising from blood-stage treatment failure (recrudescence), reinfection or relapse.
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Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites - Nature Communications

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By Sasha V. Siegel, Hidayat Trimarsanto, Roberto Amato, Edwin Sutanto, James Watson, Mallika Imwong, Ashenafi Assefa, Julian C. Rayner, Ric N. Price, Mariana Kleinecke, Awab Ghulam Rahim
| Nature Verified
Abstract Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of antimalarial efficacy and transmission. Recurrent infections may arise from activation of dormant liver stages (relapse), blood-stage treatment failure (recrudescence) or reinfection. Molecular inference of familial relatedness (identity-by-descent or IBD) can help resolve the probable origin of recurrences. As whole genome sequencing of P.
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