Hongying Shan
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IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome
PCOS Polycystic ovary syndrome CON Control STAT3 Signal transducer and activator of transcription 3 IL-22 Interleukin 22 IGFBP5 Insulin-like growth factor binding protein 5 DHEA Dehydroepiandrosterone DHT Dihydrotestosterone CK7 Cytokeratin-7 E-cad E-cadherin DEGs Differential expressed genes KEGG analysis Kyoto Encyclopedia of Genes and Genomes analysis GSEA Gene set enrichment analysis ERα Estrogen receptor α PR Progesterone receptor PAEP Progestagen associated endometrial protein SPP1...
Women with polycystic ovary syndrome exhibit impaired endometrial receptivity with excessive ERα and histone lactylation - Nature Communications
Abstract Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women and severely impairs fertility. Extant clinical studies can only provide indirect and plausible evidence to support endometrial dysfunction as an ovary-independent contributor to PCOS infertility, considering heterogeneous confounders in their phenotypes, comorbidities, and severities.
Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors
Abstract Objective To investigate the relationship between sleep quality and vertigo severity among patients with benign paroxysmal positional vertigo (BPPV) and to elucidate the mediating effects of anxiety and depression on this association. Methods We analyzed baseline data from an ongoing cohort study of 1056 BPPV patients in Northwest China.
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