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Barbara A. Hutten on Muck Rack

Barbara A. Hutten

As seen in: Nature, MDPI, JAMA: Journal of the American Medical Association, The International Journal of Behavioral Nutrition and Physical Activity, Atherosclerosis
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Articles

Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial

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By Artemiy Kovynev, Marcos F. Fondevila, Michiel C. Mommersteeg, Christian R Ramakers, Barbara A. Hutten, Bart J. Verwer, Marije S Vlug, Anne Vrieze, Maurice B. Bizino, Djuna L. Cahen, Robert C. Verdonk, Wouter De Jonge, Michail Doukas, Joanne Verheij, Ulrich Beuers, Geert D’Haens, Joost P. H. Drenth, Tamar Tchkonia, Bernd Schnabl, James Kirkland, Abraham S. Meijnikman, Mijra Koning, Eliza J. M. Ruhe, Teaco Kuiper, Maarten van den Berg, Annewieke van den Beld, Luuk Berk, Thomas Boerlage, Quinten J. J. Augustijn, Weena J. Chen, Sandjai Ramsoekh, Sanne M. M. Vermorgen, R. B. Takkenberg, Jacques J. G. Bergman
| Nature Verified
Abstract Cellular senescence plays an important role in hepatic inflammation and fibrosis1,2,3. However, whether senescence represents a potential therapeutic target in humans with metabolic dysfunction-associated steatohepatitis (MASH) remains unexplored. Here we report the results of a phase-2, double-blind, randomized, placebo-controlled trial of intermittent senolytic therapy with dasatinib plus quercetin (D + Q) in participants with fibrotic MASH.
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How Genetic Variants in Children with Familial Hypercholesterolemia Not Only Guide Detection, but Also Treatment

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By Willemijn E. Corpeleijn, Barbara A. Hutten, Albert Wiegman
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Sibbeliene E. van den Bosch 1,*, Willemijn E. Corpeleijn 1, Barbara A.
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Ideal cardiovascular health at age 5-6 years and cardiometabolic outcomes in preadolescence

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By Mette Stavnsbo, Barbara A. Hutten, Mai JM Chinapaw, Hester Jaspers Faijer-Westerink
| The International Journal of Behavioral Nutrition and Physical Activity Verified
Abstract Background The American Heart Association (AHA) developed a definition of ideal cardiovascular health (ICH) based on the presence of both ideal health behaviours (diet, physical activity, weight status and smoking) and ideal health factors (glucose, total cholesterol and blood pressure levels). However, research of ICH in the paediatric population is scarce.
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