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Mijra Koning on Muck Rack

Mijra Koning

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Articles

Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial

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By Artemiy Kovynev, Marcos F. Fondevila, Michiel C. Mommersteeg, Christian R Ramakers, Barbara A. Hutten, Bart J. Verwer, Marije S Vlug, Anne Vrieze, Maurice B. Bizino, Djuna L. Cahen, Robert C. Verdonk, Wouter De Jonge, Michail Doukas, Joanne Verheij, Ulrich Beuers, Geert D’Haens, Joost P. H. Drenth, Tamar Tchkonia, Bernd Schnabl, James Kirkland, Abraham S. Meijnikman, Mijra Koning, Eliza J. M. Ruhe, Teaco Kuiper, Maarten van den Berg, Annewieke van den Beld, Luuk Berk, Thomas Boerlage, Quinten J. J. Augustijn, Weena J. Chen, Sandjai Ramsoekh, Sanne M. M. Vermorgen, R. B. Takkenberg, Jacques J. G. Bergman
| Nature Verified
Abstract Cellular senescence plays an important role in hepatic inflammation and fibrosis1,2,3. However, whether senescence represents a potential therapeutic target in humans with metabolic dysfunction-associated steatohepatitis (MASH) remains unexplored. Here we report the results of a phase-2, double-blind, randomized, placebo-controlled trial of intermittent senolytic therapy with dasatinib plus quercetin (D + Q) in participants with fibrotic MASH.
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