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Bart J. Verwer on Muck Rack

Bart J. Verwer

As seen in: Color Research & Application, Nature
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Articles

Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial

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By Artemiy Kovynev, Marcos F. Fondevila, Michiel C. Mommersteeg, Christian R Ramakers, Barbara A. Hutten, Bart J. Verwer, Marije S Vlug, Anne Vrieze, Maurice B. Bizino, Djuna L. Cahen, Robert C. Verdonk, Wouter De Jonge, Michail Doukas, Joanne Verheij, Ulrich Beuers, Geert D’Haens, Joost P. H. Drenth, Tamar Tchkonia, Bernd Schnabl, James Kirkland, Abraham S. Meijnikman, Mijra Koning, Eliza J. M. Ruhe, Teaco Kuiper, Maarten van den Berg, Annewieke van den Beld, Luuk Berk, Thomas Boerlage, Quinten J. J. Augustijn, Weena J. Chen, Sandjai Ramsoekh, Sanne M. M. Vermorgen, R. B. Takkenberg, Jacques J. G. Bergman
| Nature Verified
Abstract Cellular senescence plays an important role in hepatic inflammation and fibrosis1,2,3. However, whether senescence represents a potential therapeutic target in humans with metabolic dysfunction-associated steatohepatitis (MASH) remains unexplored. Here we report the results of a phase-2, double-blind, randomized, placebo-controlled trial of intermittent senolytic therapy with dasatinib plus quercetin (D + Q) in participants with fibrotic MASH.
Open in Who Shared Issue with article?

Biochemical efficacy of tioguanine in autoimmune hepatitis: a retrospective review of practice in the Netherlands

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By Bart J. Verwer, Elisabeth Bloemena, Christine M. Bakker, Jan M. Vrolijk
| Color Research & Application Verified
Azathioprine (AZA) and mercaptopurine (MP) are the cornerstone of steroid‐sparing strategies in autoimmune hepatitis (AIH). Up to 20% of patients do not tolerate or respond to these regimens. To retrospectively evaluate the tolerability and efficacy of tioguanine (thioguanine) (TG) therapy in selected patients with AIH and AIH variant syndromes. Records of 52 patients who received TG therapy were retrieved from nine hospitals in the Netherlands.
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