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Barbara Bosch on Muck Rack

Barbara Bosch

As seen in: Nature, Wiley Online Library, Die Welt, BioRxiv, Cell Press, The Journal of Allergy & Clinical Immunology
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Articles

Transcription co-inhibition alters drug resistance evolution and enhances Mycobacterium tuberculosis clearance from granulomas - Nature Microbiology

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By Barbara Bosch, Vanisha Munsamy-Govender, Jansy P. Sarathy, Mirjana Lilic, Pranav Nalam, Adrian Richter, Jeremy M. Rock, Marcell Simon
| Nature Verified
Abstract Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, remains the deadliest human pathogen. Treatment is hampered by drug resistance and the persistence of slow-growing or non-replicating populations. Rifampicin, a cornerstone of first-line therapy, inhibits transcription during promoter escape, but resistance mutations undermine efficacy and drive resistance spread.
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RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation

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By Joshua Brewer, Koe Inlow, Rachel Mooney, Barbara Bosch
| BioRxiv
Abstract Following transcript release during intrinsic termination, Escherichia coli RNA polymerase (RNAP) often remains associated with DNA in a post-termination complex (PTC). RNAPs in PTCs are removed from the DNA by the Swi2/Snf2 ATPase RapA. Here, we determined PTC structures on negatively-supercoiled DNA as well as of RapA engaged to dislodge the PTC. We found that core RNAP in the PTC can unwind DNA and initiate RNA synthesis but is prone to producing R-loops.
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Weak links: Advancing target‐based drug discovery by identifying the most vulnerable targets

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By Barbara Bosch, Michael DeJesus, Dirk Schnappinger, Jeremy M. Rock
| Wiley Online Library Verified
INTRODUCTION Despite the availability of antibiotics, Mycobacterium tuberculosis (Mtb) is the world's leading bacterial killer, claiming an estimated 1.3 million lives each year.1 Treatment of drug-susceptible tuberculosis (TB) consists of a standard 4- to 6-month course of four antimicrobial drugs.
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