Barbara Cellini

Introduction Many biomolecules—like nucleic acids, proteins, lipids, and cofactors—are necessary to sustain the complex biochemistry that powers living organisms. However, how these lifeless components initially assembled to form the first active entities remains one of science's unanswered questions.

Keywords Metabolic liver disease primary hyperoxaluria type 1 alanine:glyoxylate aminotransferase 1 variants of unknown significance AGXT-KO HepG2 1 Introduction Primary hyperoxaluria type 1 (PH1; OMIM 259900) is a rare genetic disorder caused by inherited genetic variants on the AGXT gene encoding alanine:glyoxylate aminotransferase (AGT1) [1-3].

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