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Epigenetic profiles of tissue informative CpGs inform ALS disease status and progression - Genome Medicine
A total of 192 participants were enrolled in a prospective manner at the UCSF ALS Clinic in San Francisco, California, USA, the Royal Brisbane and Women’s Hospital and Mater Hospital in Brisbane, Australia under neurologist supervision from 2018–2021. All participants provided written informed consent and the study received approval from the Human Research Ethics Committee at the Royal Brisbane and Women’s Hospital (HREC/17/QRBW/299) and by the UCSF Committee on Human Research (IRB 10–05027).
In This Issue | PNAS
EVOLUTION Developing embryos of Dendropsophus sarayacuensis. Egg-laying flexibility and terrestrial reproduction Around half of all frog species lay eggs on land, but how terrestrial reproduction evolved is unclear. Justin Touchon et al. examined the egg-laying behavior of 13 species of Dendropsophus frogs in Central and South America. In behavioral experiments, the authors found, six species could lay eggs both in and out of the water and on surfaces such as overhanging branches or leaves.
Tiny and contentious “crystal clocks” in volcanic rocks could aid early warning for eruptions
Mount Taranaki is a sleeping giant. The volcano, New Zealand’s second-highest peak, rises some 2,500 meters from foggy lowlands to a snowcapped summit. It last oozed hot rocks and gases in the mid-19th century, and it’s anyone’s guess when it might erupt again. But the very rock of this place, the ridges and boulders that beckon 20,000 visitors a year, could hold clues about the timing of Taranaki’s next eruption.
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