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Bárbara Costa on Muck Rack

Bárbara Costa

As seen in: Nature, Wiley Online Library, MDPI, Revista CEFAC, Observador, Consultor Jurídico, Dialnet - Universidad de La Rioja, JOTA, Showmetech, brasiliainfoco.com
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Articles

Retraction Note: Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

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By Simona Daniele, Bárbara Costa, Elisa Zappelli, Eleonora Da Pozzo, Simona Sestito, Pietro Campiglia, Luciana Marinelli, Ettore Novellino, Simona Rapposelli, Claudia Martini, Giulia Nesi
| Nature Verified
Retraction of: Scientific Reports https://doi.org/10.1038/srep09956, published online 21 April 2015 The Editors have retracted this Article. After publication, concerns were raised about Figure 7a. An editorial investigation determined that there appears to be an overlap between the two middle control group panels, as well as overlap in the ISA27 panels. The Authors provided some data on request, but the Editors were not able to verify it.
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Therapeutic targets in luminal breast cancer: mechanisms of action, clinical evidence, and implementation challenges

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By Isabelle Pinto, Maria Felipe, Bárbara Costa
| Dialnet - Universidad de La Rioja
español El cáncer de mama luminal con receptores hormonales positivos es el tipo de cáncer más frecuente entre las mujeres. La progresión de la enfermedad se caracteriza a menudo por el desarrollo de resistencia a las terapias endocrinas, un proceso que suele estar mediado por la hiperactivación de la vía de señalización PI3K/AKT. Objetivo: Evaluar el mecanismo de acción, la evidencia clínica y los retos de implementación de un inhibidor pan-AKT para el cáncer de mama luminal avanzado.
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Using Stochastic Simulation-Estimation and Automated Model Development to Assess Power and Accuracy for Covariate Identification

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By Ya-Han Hsu, Bárbara Costa, Nuno Vale
| Wiley Online Library Verified
1 Introduction Clinical trial simulations are widely used in planning studies designed to evaluate drug therapies [1]. Population pharmacokinetic (PopPK) and pharmacodynamic (PopPD) models are typically used when longitudinal data are to be simulated [2]. In some situations, PopPK/PD models will also be used to analyze the actual trial results.
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