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Barbara Guarino on Muck Rack

Barbara Guarino

As seen in: Cell Press
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Articles

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

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By Luca Piccoli, Young-Jun Park, M. Alejandra Tortorici, Nadine Czudnochowski, Alexandra C. Walls, Martina Beltramello, Dora Pinto, Laura Rosen, John Bowen, Barbara Guarino, Chiara Silacci-Fregni, Oliver J. Acton, Stefano Jaconi, Andrea Minola
| ScienceDirect Verified
Highlights • SARS-CoV-2 RBD is immunodominant and accounts for 90% of serum neutralizing activity • RBD antibodies decline with a half-life of ∼50 days, but their avidity increases • Structural definition of a SARS-CoV-2 RBD antigenic map using monoclonal antibodies • ACE2-binding site dominates SARS-CoV-2 polyclonal neutralizing antibody responses Summary Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2 infection is crucial for understanding...
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By Davide Corti, Patrick Collins, Nicole L. Kallewaard, Ursula Neu, Josephine M. McAuliffe, Ebony Benjamin, Leslie Wachter-Rosati, Frances J. Palmer-Hill, Andy Q. Yuan, Philip A. Walker, Matthias K. Vorlaender, Siro Bianchi, Barbara Guarino, Anna De Marco
| secure.jbs.elsevierhealth.com
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