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Barbara J. Flynn on Muck Rack

Barbara J. Flynn

As seen in: Daily Express, Science Magazine, Scottish Daily Record, BioRxiv, Cell Press, Cell Reports, Times Union (Albany)
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Articles

Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates

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By Juan I. Moliva, Shayne F. Andrew, Barbara J. Flynn, Danielle Wagner
| BioRxiv
Abstract SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there's a need for vaccines that induce mucosal immunity and can rapidly control the virus.
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Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates

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By Matthew Gagne, Barbara J. Flynn, Shayne F. Andrew, Dillon R. Flebbe
| BioRxiv
Abstract Waning immunity and continued virus evolution have limited the durability of protection from symptomatic infection mediated by intramuscularly (IM)-delivered mRNA vaccines against COVID-19 although protection from severe disease remains high. Mucosal vaccination has been proposed as a strategy to increase protection at the site of SARS-CoV-2 infection by enhancing airway immunity, potentially reducing rates of infection and transmission.
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RBD-based high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways

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By Matthew Gagne, Barbara J. Flynn, Christopher Cole Honeycutt, Dillon R. Flebbe
| BioRxiv
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