Barbara M. Klinkhammer

Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Cholesterol crystal embolism (CCE) is a complication of atherosclerosis that is potentially life-threatening. Emboli can result in ischemic tissue damage including acute kidney injury (AKI) for which there are limited therapeutic options. Shi et al.

Abstract Fibrosis represents the uncontrolled replacement of parenchymal tissue with extracellular matrix (ECM) produced by myofibroblasts. While genetic fate-tracing and single-cell RNA-Seq technologies have helped elucidate fibroblast heterogeneity and ontogeny beyond fibroblast to myofibroblast differentiation, newly identified fibroblast populations remain ill defined, with respect to both the molecular cues driving their differentiation and their subsequent role in fibrosis.

Ethics statement Data collection and analysis in this study was performed in accordance with the Declaration of Helsinki and was approved by the local ethics committee of the RWTH Aachen University (EK-No. 315/19). All analyses were performed retrospectively in an anonymous fashion and the need for informed consent was waived by the local ethics and privacy committee for all datasets.