Barbara Pernaute

Highlights • Mouse oocytes store protein aggregates in endolysosomal vesicular assemblies (ELVAs) • ELVAs harbor endolysosomes, autophagosomes, and proteasomes in a liquid-like matrix • ELVAs degrade aggregates upon oocyte maturation to promote healthy embryogenesis • Retention of protein aggregates in the embryo leads to early embryonic arrest Summary Oocytes are among the longest-lived cells in the body and need to preserve their cytoplasm to support proper embryonic development.

The relative expression of pro- and anti-apoptotic BCL2 family members does not explain the different apoptotic thresholds of ESCs and EpiSCs To address if differences in the relative expression of pro- and anti-apoptotic BCL2 family members underpin the different apoptotic response of ESCs and EpiSCs, we compared the expression of these proteins in each cell type.

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