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ddMVAC versus gemcitabine–cisplatin as neoadjuvant treatment for muscle-invasive urothelial bladder cancer: a multicenter real-world study
Abstract Cisplatin-based neoadjuvant chemotherapy (NACT) followed by radical cystectomy (RC) is the standard treatment for eligible patients with muscle-invasive bladder cancer (MIBC). However, the comparative effectiveness of gemcitabine/cisplatin (GC) and dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) in routine practice remains insufficiently defined, particularly in broader real-world populations that include patients with regional lymph node involvement.
20 Impact of Ribociclib Dose Reduction on Efficacy in Patients With Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Early Breast
Background The NATALEE trial showed statistically significant and clinically meaningful invasive disease-free survival (iDFS) with ribociclib plus a nonsteroidal aromatase inhibitor (NSAI) vs NSAI in patients with stage II/III hormone receptor–positive (HR+)/HER2-negative (HER2–) early breast cancer (EBC; HR, 0.715; 95% CI, 0.609-0.840; 4-year absolute benefit, 4.9%; median follow-up, 44.2 months). We present an exploratory analysis of efficacy in patients with and without dose reduction.
Biomedicines | Free Full-Text | Predictive and Prognostic Role of Systemic Immune-Inflammation Index (SII) in Metastatic Colorectal Cancer Patients Treated with Trifluridine/Tipiracil
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