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Barbara Tevelev on Muck Rack

Barbara Tevelev

As seen in: AIChE Journal
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Articles

A Genetic Off‐Target Event in a Site‐Specific Integration Cell Line Expressing Monoclonal Antibody has no Impact on Commercial Suitability

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By Barbara Tevelev, Andre Alonzo Chambers, Swap Ghosh, Ying Zhang
| AIChE Journal Verified
Abstract Site-specific integration (SSI) cell line systems are gaining popularity for biotherapeutic development and production. Despite the proven advantages for these expression hosts, the SSI system is still susceptible to rare off-target events and potential vector rearrangements. Here we describe the development process of an SSI cell line for production of an IgG1 monoclonal antibody (mAb-086).
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Genetic Rearrangement During Site Specific Integration Event Facilitates Cell Line Development of a Bispecific Molecule

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By Barbara Tevelev, Himakshi Patel, Kathleen Shields, Wei Wei
| AIChE Journal Verified
RESEARCH ARTICLE Himakshi Patel Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA Contribution: Data curation, Formal analysis, ​Investigation, Methodology, Writing - review & editing Search for more papers by this author Wei Wei Cell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA Contribution: Conceptualization, Data curation, Formal analysis, Methodology, Writing - review & editing Search for more...
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