Swap Ghosh on Muck Rack

Swap Ghosh

As seen in: AIChE Journal, Nature
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Articles

USTAT: Unified Sequential Template Amplification and Transcription—a fully synthetic mRNA manufacturing platform

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By Swap Ghosh, Carrie L. Simms, Carlos Castañeda Verified, Joseph W. Saelens, Michael Swyers, Joseph Russo, Sage D. Rohrer, Kaley Niehaus
| Nature Verified
Abstract mRNA vaccines have emerged as a transformative modality for infectious disease prevention. In response to the emergence of SARS-CoV-2, large-scale in vitro transcription (IVT) of mRNA vaccines was developed. Large-scale IVT currently relies on linearized plasmid DNA (pDNA) as a template for mRNA production. Linearized pDNA production presents several challenges at manufacturing scale, including removal of residual host-cell DNA, protein, endotoxins, and antibiotics.
Open in Who Shared Issue with article?

A Genetic Off‐Target Event in a Site‐Specific Integration Cell Line Expressing Monoclonal Antibody has no Impact on Commercial Suitability

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By Barbara Tevelev, Andre Alonzo Chambers, Swap Ghosh, Ying Zhang
| AIChE Journal Verified
Abstract Site-specific integration (SSI) cell line systems are gaining popularity for biotherapeutic development and production. Despite the proven advantages for these expression hosts, the SSI system is still susceptible to rare off-target events and potential vector rearrangements. Here we describe the development process of an SSI cell line for production of an IgG1 monoclonal antibody (mAb-086).
Open in Who Shared Issue with article?
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