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Barbara Zunino on Muck Rack

Barbara Zunino

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Articles

mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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By Florian Beaumatin, Jim O’Prey, Valentin J.A. Barthet, Barbara Zunino
| Cell Press Verified
Highlights • DRAM-1 is required for efficient activation of the nutrient-sensing complex mTORC1 • DRAM-1 and SCAMP3 direct newly synthesized amino acid transporters to lysosomes • DRAM-1 drives lysosomal amino acid efflux to promote mTORC1 activation • Loss of DRAM-1 increases insulin sensitivity and enhances adipocyte differentiation Summary Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process.
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