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Species-specific cleavage of the autophagy adaptor p62 dictates responses to TNF
Keywords cell death caspase TNF autophagy p62 mice Introduction Inflammation is a tissue state involved in infection and immunity1 as well as other diseases, including arthritis, inflammatory bowel disease, and cancer.2 One important group of factors involved in inflammation are the ligands of the TNF (tumor necrosis factor) receptor superfamily. TNF is the archetypal member of the family and can signal via two receptors: TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2).
Senescence in cancer: Hallmarks, paradoxes, and therapeutic promise
Get full text access Log in, subscribe or purchase for full access. References 1. Hayflick, L. ∙ Moorhead, P.S. The serial cultivation of human diploid cell strains Exp. Cell Res. 1961; 25:585-621 2. Hayflick, L. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS Exp. Cell Res. 1965; 37:614-636 3. Campisi, J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors Cell. 2005; 120:513-522 4. Campisi, J. ∙ d'Adda di Fagagna, F.
1,2 1Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; 2Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA Corresponding author: lowes{at}mskcc.org Footnotes Article published online ahead of print. Article and publication date are online at http://www.genesdev.org/cgi/doi/10.1101/gad.353134.125.
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