Barbora Huraiova

Current assays fail to address breast cancer's complex biology and accurately predict treatment response. On a retrospective cohort of 1082 female breast tissues, we develop and validate mFISHseq, which integrates multiplexed RNA fluorescent in situ hybridization with RNA-sequencing, guided by laser capture microdissection. This technique ensures tumor purity, unbiased whole transcriptome profiling, and explicitly quantifies intratumoral heterogeneity.

During sexual reproduction, two haploid cells fuse to produce a diploid cell called a zygote. A new study describes how fission yeast prevents a zygote from being formed by the fusion of more than two cells. Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost. Click here to explore this opportunity. To read this article in full you will need to make a payment Juno is the egg Izumo receptor and is essential for mammalian fertilization.

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