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Barry Chioza

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Articles

Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex

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By Alice Franklin, Jonathan Davies, Nicholas E. Clifton, Georgina Blake, Rosemary A. Bamford, Emma Walker, Barry Chioza, Simon Baron-Cohen, Carrie Allison, Varun Warrier, Alex Tsompanidis, Deep Adhya, Rosie Holt, Joanna O'Donnell Verified, Niran Okewole, Daniel H Geschwind, Alexander E.P. Heazell, Jonathan Mill, Matthew E Hurles, Hilary C. Martin, Mahmoud M. Mousa, David H. Rowitch, Kathy K. Niakan, Graham J Burton, Deepak Srivastava, Lucia Dutan-Polit, Adam Pavlinek, Laura Sichlinger, Roland Nagy, Madeline A. Lancaster, Jose Gonzalez-Martinez, Tal Biron-Shental, Lidia V. Gabis, Dori Floris, Richard A. I. Bethlehem, Mike Lombardo, Marcin A. Radecki, Meng-Chuan Lai, Elizabeth Weir, Florina Uzefovsky, Yumnah T. Khan, Anna A. Penn, Rebecca C. Knickmeyer, Kyriaki Kosidou, Bart P Rutten, Sinan Guloksuz, Thérèse van Amelsvoort, Lotta-Katrin Pries, Bochao Danae Lin, Angelo Arias-Magnasco, Mary Cannon, David Cotter, Melanie Föcking, Subash Raj Susai, Elisabeth Binder Verified, Jim van Os, Jeroen Pasterkamp, Anna L. Wiersema, Marco P. Boks, Winni Schalkwijk, Karim Lekadir, Esmeralda Ruiz Pujadas, Ian Kelleher, Jenni Leppanen, Valentina Kieseppä, Simona Karbouniaris, Marijke Kolk, Jordi Rambla, Arcadi Navarro, Liina Nagirnaja, Jaanus Harro, Dejan Stevanovic, Jasna Jancic, Marija Nikolić, Laura Giani, Tomislav Franic, Mia Plenkovic, Covadonga M Díaz-Caneja, Celso Arango, Christel M. Middeldorp, Enda M. Byrne, Sushma Marla, Eilis Hannon, Emma Dempster, Philippa M Wells, Robin Murray Verified, Andrea Danese, Alexander Richards, Lucy Riglin, Michael O’Donovan, Joe Burrage, Nick Owens, Shyam Prabhakar, Martyn Frith, Genie Gu, Yira Zhang, Omar Al-Rubaie, Fateneh Ghafari, Yeshaya David Greenberg, Erika van Hell, Noussair Lazrak, Mariël Kanne, Hanske Douwenga, Aldar Cabrelles Munoz, Lauren A. Fromont, Triin Kurrikoff, Reigo Reppo, Aleksa Milevic, Maria Bulgheroni, Margherita La Gamba, Marta Ferrer-Quintero, Renzo Abregú-Crespo, Emily Guerra-Blacio, Nuria Martín-Martínez, Swathi Hassan Gangaraju
| Cell Press Verified
Keywords DNA methylation cortex development aging schizophrenia autism epigenetics fetal brain neuronal Introduction Development of the human cortex is a complex and highly orchestrated process underpinned by the temporally coordinated regulation of gene expression.1 Starting with the rapid proliferation of neural progenitor cells in the ventricular zone, these transcriptional programs drive key developmental processes, including neurogenesis and synaptogenesis, and act to regulate neuronal...
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Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology - Nature Communications

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By Szi Kay Leung, Aaron R Jeffries, Isabel Castanho, Barry Chioza, Karen Moore, Emma Dempster, Joshua Harvey, Sarah Richardson, Eilis Hannon
| Nature Verified
Abstract Increasing evidence suggests that alternative splicing plays an important role in Alzheimer’s disease (AD) pathology. We used long-read sequencing in combination with a novel bioinformatics tool (FICLE) to profile transcript diversity in the entorhinal cortex of female transgenic (TG) mice harboring a mutant form of human tau.
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Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles

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By Eilis Hannon, Emma Dempster, Barry Chioza, Jonathan Davies
| BioRxiv
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