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Eilis Hannon on Muck Rack

Eilis Hannon

Exeter, Taunton
As seen in: Nature, Genome Biology, Genome Medicine, BioRxiv, Cell Press, eLife, Alzheimer's & Dementia
Mathematician turned Bioinformatician. EPSRC Research Software Enginerring Fellow. Wannabe domestic goddess, one science themed cake at a time.
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Articles

Proteomic signatures of smoking and their associations with risk of incident diseases and mortality in diverse populations - Nature Communications

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By M. Austin Argentieri, Claire Shovlin, Jennifer Collister, Eilis Hannon, Jun Liu, KaHung Chan, Jun Lv, Dianjianyi Sun, Jonathan Mill, Robert Clarke, Zhengming Chen, Najaf Amin
| Nature Verified
Abstract Smoking is the most important behavioural determinant of morbidity and mortality. Using machine learning on plasma levels of 2,917 proteins in the UK Biobank (n = 43,914), we develop a proteomic Smoking Index (pSIN) comprising 51 proteins that accurately distinguish current from never smokers (AUC = 0.95; 95% CI 0.94–0.95). Validation in the China Kadoorie Biobank (n = 3,977) shows similar accuracy (AUC = 0.91; 95% CI 0.89–0.92).
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Explainable deep learning for DNA methylation analysis in health and disease

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By Mika Gustafsson, Björn Wallner, Eilis Hannon, Linköpings universitet
| avhandlingar.se
Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Deep learning; Autoencoders; DNA methylation; Aging; Health; Sammanfattning: Modern clinical decision support requires models that are both accurate and mechanistically interpretable. DNA methylation tracks the cumulative influence of development, lifestyle, and environment on gene regulation, but its dimensionality and tissue specificity complicate analysis and clinical application.
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Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex

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By Alice Franklin, Jonathan Davies, Nicholas E. Clifton, Georgina Blake, Rosemary A. Bamford, Emma Walker, Barry Chioza, Simon Baron-Cohen, Carrie Allison, Varun Warrier, Alex Tsompanidis, Deep Adhya, Rosie Holt, Joanna O'Donnell Verified, Niran Okewole, Daniel H Geschwind, Alexander E.P. Heazell, Jonathan Mill, Matthew E Hurles, Hilary C. Martin, Mahmoud M. Mousa, David H. Rowitch, Kathy K. Niakan, Graham J Burton, Deepak Srivastava, Lucia Dutan-Polit, Adam Pavlinek, Laura Sichlinger, Roland Nagy, Madeline A. Lancaster, Jose Gonzalez-Martinez, Tal Biron-Shental, Lidia V. Gabis, Dori Floris, Richard A. I. Bethlehem, Mike Lombardo, Marcin A. Radecki, Meng-Chuan Lai, Elizabeth Weir, Florina Uzefovsky, Yumnah T. Khan, Anna A. Penn, Rebecca C. Knickmeyer, Kyriaki Kosidou, Bart P Rutten, Sinan Guloksuz, Thérèse van Amelsvoort, Lotta-Katrin Pries, Bochao Danae Lin, Angelo Arias-Magnasco, Mary Cannon, David Cotter, Melanie Föcking, Subash Raj Susai, Elisabeth Binder Verified, Jim van Os, Jeroen Pasterkamp, Anna L. Wiersema, Marco P. Boks, Winni Schalkwijk, Karim Lekadir, Esmeralda Ruiz Pujadas, Ian Kelleher, Jenni Leppanen, Valentina Kieseppä, Simona Karbouniaris, Marijke Kolk, Jordi Rambla, Arcadi Navarro, Liina Nagirnaja, Jaanus Harro, Dejan Stevanovic, Jasna Jancic, Marija Nikolić, Laura Giani, Tomislav Franic, Mia Plenkovic, Covadonga M Díaz-Caneja, Celso Arango, Christel M. Middeldorp, Enda M. Byrne, Sushma Marla, Eilis Hannon, Emma Dempster, Philippa M Wells, Robin Murray Verified, Andrea Danese, Alexander Richards, Lucy Riglin, Michael O’Donovan, Joe Burrage, Nick Owens, Shyam Prabhakar, Martyn Frith, Genie Gu, Yira Zhang, Omar Al-Rubaie, Fateneh Ghafari, Yeshaya David Greenberg, Erika van Hell, Noussair Lazrak, Mariël Kanne, Hanske Douwenga, Aldar Cabrelles Munoz, Lauren A. Fromont, Triin Kurrikoff, Reigo Reppo, Aleksa Milevic, Maria Bulgheroni, Margherita La Gamba, Marta Ferrer-Quintero, Renzo Abregú-Crespo, Emily Guerra-Blacio, Nuria Martín-Martínez, Swathi Hassan Gangaraju
| Cell Press Verified
Keywords DNA methylation cortex development aging schizophrenia autism epigenetics fetal brain neuronal Introduction Development of the human cortex is a complex and highly orchestrated process underpinned by the temporally coordinated regulation of gene expression.1 Starting with the rapid proliferation of neural progenitor cells in the ventricular zone, these transcriptional programs drive key developmental processes, including neurogenesis and synaptogenesis, and act to regulate neuronal...
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