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Bart De Strooper

As seen in: Nature, The Guardian, Daily Express, JAMA (The Journal of the American Medical Association), Science Magazine, BioRxiv, Cell Press, Stem Cell Reports, The Lancet, The Journal of Biological Chemistry
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Articles

Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience

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By Ashley Lu, Wei-Ting Chen, Maria Dalby, DIEGO GARCÍA Verified, Marisa Vanheusden, Luuk De Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick F. Swaab, Dietmar Rudolf Thal, Inge Huitinga, Annemieke J.M. Rozemuller, Susan Rohde, Marc Hulsman, Henne Holstege, Rita Balice-Gordon, Niels Plath, Mark Fiers, Bart De Strooper
| Nature Verified
Abstract Alzheimer’s disease (AD) is not an inevitable outcome of pathology but a dynamic process shaped by how brain cells respond to amyloid-β (Aβ) and tau. To disentangle these responses, we combined spatial transcriptomics and single-nucleus RNA sequencing of the superior frontal cortex from octogenarians living with or without dementia and from cognitively intact centenarians with comparable Aβ accumulation.
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Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived neuron xenografts

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By Carles Calatayud, Sriram Balusu, Nicolas Peredo, Katlijn Vints, Katrien Horré, Bart De Strooper, Patrik Verstreken, Nicolò Carrano, Sandra Fernández Gallego
| Stem Cell Reports Verified
ArticleVolume 21, Issue 1102754Open access 1VIB KU Leuven Center for Brain & Disease Research, Leuven, Belgium 2KU Leuven, Department of Neurosciences, Leuven Brain Institute, 3000 Leuven, Belgium 3VIB BioImaging Core, 3000 Leuven, Belgium 4UK Dementia Research Institute, University College London, London, UK Publication History: Received May 16, 2025; Revised November 30, 2025; Accepted December 1, 2025; Published online January 2, 2026 DOI: 10.1016/j.stemcr.2025.102754 External LinkAlso...
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The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia xenografted into a mouse model of Alzheimer’s disease | Nature Communications

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By Susan Rohde, Bart De Strooper
| Nature Verified
Abstract Microglia play a key role in the response to amyloid beta in Alzheimer’s disease (AD). In this context, the major transcriptional response of microglia is the upregulation of APOE, the strongest late-onset AD risk gene. Of its three isoforms, APOE2 is thought to be protective, while APOE4 increases AD risk. We hypothesised that the isoforms change gene regulatory patterns that link back to biological function by shaping microglial transcriptomic and chromatin landscapes.
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