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Bart De Strooper

As seen in: Nature, The Guardian, Daily Express, JAMA (The Journal of the American Medical Association), Science Magazine, BioRxiv, Cell Press, Cell Reports, Stem Cell Reports, The Lancet and
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Articles

Inflection points and transitions in Alzheimer’s disease

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By Bart De Strooper, Eric Karran
| Nature Verified
Abstract Alzheimer’s disease is widely depicted as a linear cascade from amyloid-β accumulation to Tau pathology and neurodegeneration. We propose instead that the disease unfolds through discrete molecular, cellular and network phases organized around biological inflection points. At these thresholds, stress-driven loss of homeostasis produces qualitative shifts in cellular behavior that alters disease progression.
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APOE3 and APOE4 human astrocytes differentially modulate Alzheimer’s disease pathology and microglial responses in chimeric mice

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By Joan Cruz-Sese, Marta Miron-Alcala, Maria Alfonso-Triguero, Jon Olalde, Leire Toscano Ruiz, Laura Escobar, An Snellinx, Takashi Saito, Takaomi C. Saido, Ana M. Aransay, Ibai Diez, Julia TCW, Alison Goate, Bart De Strooper, Elena Alberdi, Amaia Arranz, Nuria Galbis-Gramage, Lorea Cortes, Pranav Preman, Laura Saiz-Aúz, Alberto Rábano-Gutiérrez
| Cell Reports Verified
Keywords Alzheimer's disease AD human astrocytes hAstrocytes human induced pluripotent stem cells hiPSCs chimeric mice apolipoprotein E APOE amyloid-beta Aβ Research topic(s) CP: neuroscience CP: stem cell research Introduction The apolipoprotein E (APOE4) variant of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD).
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Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience

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By Ashley Lu, Wei-Ting Chen, Maria Dalby, DIEGO GARCÍA Verified, Marisa Vanheusden, Luuk De Vries, Veerle van Lieshout, Araks Martirosyan, Katleen Craessaerts, Sebastiaan Moonen, Magdalena Zielonka, Iordana Chrysidou, Anke Misbaer, Leen Wolfs, Benjamin Pavie, Dick F. Swaab, Dietmar Rudolf Thal, Inge Huitinga, Annemieke J.M. Rozemuller, Susan Rohde, Marc Hulsman, Henne Holstege, Rita Balice-Gordon, Niels Plath, Mark Fiers, Bart De Strooper
| Nature Verified
Abstract Alzheimer’s disease (AD) is not an inevitable outcome of pathology but a dynamic process shaped by how brain cells respond to amyloid-β (Aβ) and tau. To disentangle these responses, we combined spatial transcriptomics and single-nucleus RNA sequencing of the superior frontal cortex from octogenarians living with or without dementia and from cognitively intact centenarians with comparable Aβ accumulation.
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