Bart S. Ferket
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Parent-Reported Clinical Utility of Pediatric Genomic Sequencing
BACKGROUND AND OBJECTIVES: Genomic sequencing (GS) is increasingly used for diagnostic evaluation, yet follow-up care is not well understood. We assessed clinicians' recommendations after GS, parent-reported follow-up, and actions parents initiated in response to learning their child's GS results. METHODS: We surveyed parents of children who received GS through the Clinical Sequencing Evidence Generating Research consortium ∼5 to 7 months after return of results.
Cost-Effectiveness Frameworks for Comparing Genome and Exome Sequencing Versus Conventional Diagnostic Pathways: A Scoping Review and Recommended Methods
PURPOSE: Methodological challenges have limited economic evaluations of genome sequencing (GS) and exome sequencing (ES). Our objective was to develop conceptual frameworks for model-based cost-effectiveness analyses (CEAs) of diagnostic GS/ES.
Aspirin Monotherapy Is More Cost Effective than Rivaroxaban + Aspirin in Peripheral Arterial Disease Patients after Revascularization
Objectives Considerable debate exists on optimal antithrombotic therapy after lower extremity revascularization in peripheral arterial disease (PAD) patients. Multiple studies have investigated the addition of additional agents to the widely accepted aspirin monotherapy, including low-dose rivaroxaban in the Vascular Outcomes Study of Aspirin Along with Rivaroxaban in Endovascular or Surgical Limb Revascularization for PAD (VOYAGER PAD) trial.
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