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Articles

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

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By Martin-Luther-University Halle-Wittenberg, Rochester NY, Bartel DP, Pediatrics III
| Ash Publications
Skip Nav Destination PLENARY PAPER| February 3, 2022 You do not currently have access to this content. Sign in via your Institution
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System wide analyses have underestimated protein abundances and the importance of transcription in mammals

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By Wassarman DA, Camargo FD, Gygi SP, Bartel DP
| PeerJ
Introduction The protein products of genes are expressed at very different levels from each other in a mammalian cell. Thousands of genes are not detectably expressed. Of those that are, their proteins are present at levels that differ by five orders of magnitude. Cytoplasmic actin, for example, is expressed at 1.5 × 108 molecules per cell (Kislauskis, Zhu & Singer, 1997), whereas some transcription factors are expressed at only 4 × 103 molecules per cell (Biggin, 2011).
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