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Articles

Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas

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By Gygi SP, Widlund HR
| ncbi.nlm.nih.gov
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Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism

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By Sohn JH, Gygi SP, Latorre-Muro P, Bennett CF
| ncbi.nlm.nih.gov
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System wide analyses have underestimated protein abundances and the importance of transcription in mammals

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By Wassarman DA, Camargo FD, Gygi SP, Bartel DP
| PeerJ
Introduction The protein products of genes are expressed at very different levels from each other in a mammalian cell. Thousands of genes are not detectably expressed. Of those that are, their proteins are present at levels that differ by five orders of magnitude. Cytoplasmic actin, for example, is expressed at 1.5 × 108 molecules per cell (Kislauskis, Zhu & Singer, 1997), whereas some transcription factors are expressed at only 4 × 103 molecules per cell (Biggin, 2011).
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