Bartolomeo Bo

We performed a prospective single-center (University Hospital of Bonn) subgroup analysis of CDH newborns born between 2014 and 2022, who were initially enrolled in the “Biomarker forOutcomePredictionin Neonates withCongenital Diaphragmatic Hernia” (BIOPTIC) study (Clinical trial registration with German Clinical Trial Register (DKRS), trial registration number: DKRS00034329; Registration date: 24.05.2024).

AUC area under the curve CDH congenital diaphragmatic hernia CLD chronic lung disease ECMO extracorporeal membrane oxygenation FiO2 fraction of inspired oxygen HI Horovitz Index MAP mean airway pressure NPV negative predictive value OI Oxygenation Index OSI Oxygen Saturation Index PaO2 partial pressure of arterial oxygenation PCO2 partial pressure of CO2 PH pulmonary hypertension PPV positive predictive value ROC receiver operating characteristics SaO2 oxygen saturation of the blood SpO2...

1 INTRODUCTION Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 4000 life birth and its mortality is still high.1 Lung hypoplasia, pulmonary hypertension (PH), and cardiac dysfunction are major contributors to morbidity and mortality in affected patients.2-4 Currently, all international guidelines on postnatal management of CDH neonates recommend endotracheal intubation immediately following delivery for prenatally diagnosed CDH regardless of CDH severity.5, 6 The rationale...