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Articles by Bastian Popper
A novel multi-epitope vaccine induces protective and therapeutic immunity against Helicobacter pylori
Abstract The development of an effective vaccine against Helicobacter pylori remains a major global health priority, aimed at reducing infection prevalence and preventing diseases such as chronic gastritis, peptic ulcers, and gastric cancer. Despite extensive research, no vaccine has yet demonstrated durable efficacy in clinical settings. This study describes the development of a novel multi-epitope vaccine targeting H. pylori.
Prevalence and management practices of ophthalmic lesions in laboratory mice
Abstract The regular inspection of the eye health is an essential part of the veterinary care task in an animal facility in order to achieve robust results during experimentation. The aim of the study was to find out, when and how ocular diseases are recorded in laboratory animal facilities and what measures are taken. An online questionnaire was sent to people who work in a research environment and are involved in monitoring of animal wellbeing.
Detection of alpha-synuclein seeding activity in tear fluid in patients with Parkinson’s disease - npj Parkinson's Disease
Abstract Detection of alpha-synuclein (α-Syn) seeding activity in tear fluid (TF) offers a promising non-invasive biomarker for Parkinson’s disease (PD). α-Syn seeding amplification assay (αSynSAA) detected seeding activity in 67% of PD-TF, while non-synucleinopathy samples remained negative. Electron microscopy of seeding-positive end products revealed fibrillar structures morphologically consistent with results of αSynSAA.
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis
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Keywords ferroptosis GPX4 Alzheimer’s disease neurodegeneration cell death neuroinflammation spondylometaphyseal dysplasia Sedaghatian type SSMD Introduction The progressive loss of neurons is a recurring feature of neurodegenerative diseases, a diverse group of disorders characterized by cognitive decline, motor impairment, and, in many cases, premature death.1,2,3,4 Although neuronal death is a shared endpoint, each neurodegenerative condition presents with distinct pathological hallmarks,...
By Svenja Lorenz Verified, Adam Wahida, Mark J. Bostock, Tobias Seibt, Anastasia Levkina, Dietrich Trümbach, Mohamed Soudy, David Emler, Nicola Rothammer, Marcel S. Woo, Jana K. Sonner, Mariia Novikova, Bernhard Henkelmann, Maceler Aldrovandi, Daniel F. Kaemena, Eikan Mishima, Perrine Vermonden, Zhi Zong, Deng Cheng, Toshitaka Nakamura, Junya Ito, Sebastian Doll, Bettina Proneth, Erika Bürkle, Francesca Rizzollo, Abril Escamilla Ayala, Valeria Napolitano, Marta Kolonko-Adamska, Stefan Gaussmann, Juliane Merl-Pham, Stefanie Hauck, Anna Pertek, Tanja Orschmann, Emily Van San, Tom Vanden Berghe, Daniela Hass, Adriano Maida, Joris M. Frenz, Lohans Pedrera, Amalia M. Dolga, Markus Kraiger, Helmut Fuchs, Gregor Ebert, Jerica Lenberg, Jennifer Friedman, Patrizia Agostinis, Annemarie Zimprich, Daniela Vogt-Weisenhorn, Lillian Garrett, Sabine M. Hölter, Wolfgang Wurst, Enrico Glaab, Jan Lewerenz, Bastian Popper, Christian Sieben Verified, Petra Steinacker, Hans Zischka, Ana J. García-Sáez, Anna Tietze, Sanath Kumar Ramesh, Scott Ayton, Michelle Vincendeau, Manuel A. Friese, Kristen Wigby, Michael Sattler, Matthias Mann, Irina Ingold, Ashok Kumar Jayavelu, Grzegorz M. Popowicz, Marcus Conrad
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Cell Press
Verified
Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model - Alzheimer's Research & Therapy
Using phage display technology, a human immunome-derived antibody library [36, 37] was screened for binding to a peptide antigen of the human TREM2 stalk region. Antibodies were screened based on binding to human TREM2, and clones of interest were reformatted onto human effectorless human IgG1-LALA backbones for material generation and further evaluation of cell binding potency and functional impact to TREM2 signaling.
Characterization of Reusable and Recyclable Plastic Bedding Materials for Laboratory Mice
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Ribosome inactivation regulates translation elongation in neurons
Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells consistently reshape their translatome, and, consequently, their proteome. The control of translational activity has been thoroughly examined at the stage of translation initiation. However, the regulation of ribosome speed in cells is widely unknown.
Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice
CHRNA7 the alpha7 nicotinic acetylcholine receptor DAVID The Database for Annotation, Visualization and Integrated Discovery DDA data dependent acquisition KEEG Kyoto Encyclopedia of Genes and Genomes KO knockout RSLC rapid separation liquid chromatography WT wild type Nicotinic acetylcholine receptors (nAChRs) are a diverse family of ligand-gated ion channels that are composed of five subunits which assemble symmetrically around an axis perpendicular to the plasma membrane [1].
Comparative analysis of pancreatic amylase activity in laboratory rodents - Scientific Reports
Abstract Alpha-amylase is the main enzyme for starch digestion in the mammalian gastrointestinal tract. There are species differences in the enzymatic activity of pancreatic amylase that are related to the digestive strategy and natural diet of a species. This aspect is well investigated in pet and farm animals, while in common laboratory animal rodents, information is scarce.
Practicable methods for histological section thickness measurement in quantitative stereological analyses
The accuracy of quantitative stereological analysis tools such as the (physical) disector method substantially depends on the precise determination of the thickness of the analyzed histological sections. One conventional method for measurement of histological section thickness is to re-embed the section of interest vertically to its original section plane. The section thickness is then measured in a subsequently prepared histological section of this orthogonally re-embedded sample.
PLOS ONE: Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle
Members of the POU domain transcription factor family are crucially involved in the regulation of a variety of developmental processes in diverse organs and tissues [1]. Amongst others, the transcription factor POU3F3 (BRN1) plays an important role in the embryonic development of the brain and the kidney, where it participates in regulation of cerebro-cortical neuron migration [2,3] and renal distal tubule formation [4–7].
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